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Dear Colleagues,
I have a liposomal formulation and I would like to know if it is
metabolized or not (in vitro and in vivo). Any suggestion how to perform
these studies will be highly appreciated.
Abdel
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Dear Abdel,
It is not clear whether you are studying metabolism of the lipid that
makes the liposomal bilayer or the drug that you are
encapsulating/complexing? If it the drug that you wish to study,
then standard in vitro drug metabolism preps will do (S9, microsomes,
hepatocytes, liver slices, etc), depending on the drug's intrinsic
metabolic pathways. See
http://members.tripod.com/~rkrishna/index.html for updates and
information in the general area of liposomal systems.
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