Dear all, I have this put this question last week but it not see anyBack to the Top
reply from members. Can we use rats of 400+ gram (age over 16 weeks)
for PK studies? What should be the ideal weight and age of different
animals: rat, mouse, and monkey for PK studies. Any reference which
found difference in blood level or changes in PK parameters with age. I
appreciate comments from the experts. Best regards, Jagdish Jaiswal,
PhD
Dear all, I have this put this question last week but it not see anyBack to the Top
reply from members. Can we use rats of 400+ gram (age over 16 weeks)
for PK studies? What should be the ideal weight and age of different
animals: rat, mouse, and monkey for PK studies. Any reference which
found difference in blood level or changes in PK parameters with age. I
appreciate comments from the experts. Best regards, Jagdish Jaiswal,
PhD
[I'm sorry if this is a repeat. There was a 'stalled' message on my
queue last week (amongst other challenges). When I deleted that message
it seemed to allow a few other older message through. You may have
noticed some older (by a few days) messages turn up yesterday or today.
Hopefully 'things' will settle down soon - db]
Maybe there is no 'ideal' weight range other than not too young and notBack to the Top
too old ?
Question first what you are trying to achieve.
Rats and mice are used in long-term tox studies so PK data in young,
middle and
old ages may help - if that is your focus. In many respects the choice
may be
influenced by practical issues eg blood volumes, physical size for
control by
the technical operator, size of the bile-duct for cannulations etc
Dave
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