Back to the Top
The following message was posted to: PharmPK
Can you please help me with getting information on the
pharmacokinetics of heroin that explains the following,
administration, absorption, metabolism and excretion
Thanks a whole bunch.
[See
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&uid=7420276&cmd=showdetailview&indexed=google
from the first page of googling 'heroin pharmacokinetics' - db]
Back to the Top
The following message was posted to: PharmPK
Dear Deanne
A peer-reviewed overview of ADME of heroin after different
administration routes is free available on the internet:
http://www.bentham.org/ccp/samples/ccp1-1/Rook.pdf
Elisabeth J. Rook, Alwin D.R. Huitema , Wim van den Brink, Jan M. van
Ree and
Jos H. Beijnen, Pharmacokinetics and Pharmacokinetic Variability of
Heroin and its
Metabolites: Review of the Literature, Current Clinical Pharmacology,
2006;1: 109-18
Other articles regarding this subject:
E Gyr et al., Int J Clin Pharmacol Ther 2000;38(10):486-91
MG Klous et al., Pharmacokinetic comparison of two methods of heroin
smoking:chasing the dragon versus the use of a heating device. Eur
Neuropsychopharmacol. 2005; 15(3): 263-9
K . Rentsch et al, Arterial and venous pharmacokinetics of intravenous
heroin in subjects who are addicted to narcotics. Clinical Pharmacology
& Therapeutics 2001;70(3):237-46
Rook EJ, Huitema AD, van den Brink W, van Ree JM, Beijnen JH. Population
pharmacokinetics of heroin and its major metabolites. Clin
Pharmacokinet. 2006;45(4):401-17.
Ej Rook et al., Pharmacokinetics and pharmacodynamics of high doses of
pharmaceutically prepared
heroin, by intravenous or by inhalation route in opioid-dependent
patients.
Basic Clin Pharmacol Toxicol. 2006 Jan;98(1):86-96.
Best regards
Elisabeth
Back to the Top
Hi,
There is a thesis on the "Pharmacokinetics and pharmacodynamics of
diacetylmorphine in opiod dependent patients" by E.J.Rook, ISBN
90-6464-7992 with a wealth of references. EJ Rook has also published a
number of articles about her research.
Frieda Ebes
Want to post a follow-up message on this topic?
If this link does not work with your browser send a follow-up message to PharmPK@boomer.org with "Pharmacokinetics of heroin" as the subject | Support PharmPK by using the |
Copyright 1995-2011 David W. A. Bourne (david@boomer.org)