PK/PD and Other Jobs

The URL for this page is http://www.pharmpk.com/pkjob.html

Add your own entry?

Contact email address: fran@stelfoxuk.com - 14th Jun 2013 [2400]

ADME Scientific Lead – Switzerland

A fantastic opportunity has become available at a leading Pharmaceutical company renowned for its diverse and innovative work culture. The company requires a senior PhD scientist to work within the Drug Metabolism and Pharmacokinetics department (DMPK) providing scientific excellence in in vivo ADME/PK studies.

In this role you will:

You will bring to the role: If you are a successful candidate, you will benefit from: If you have the skills and experience for this opportunity and the ambition to take on this position, please call Francesca for further details or email your CV today.

Contact Francesca at +44 1273 727 930 or fran@stelfoxuk.com

Francesca is a Search expert at Stelfox Pharmaceutical Search covering Europe, UK, North America and Asia.

Contact email address: fran@stelfoxuk.com - 14th Jun 2013 [2399]

Laboratory Manager in vivo ADME/PK – Switzerland

A fantastic opportunity has become available at a leading Pharmaceutical company renowned for its diverse and innovative work culture. The company requires a senior PhD scientist to work within the Drug Metabolism and Pharmacokinetics department (DMPK) providing scientific excellence in in vivo ADME/PK studies.

In this role you will:

You will bring to the role:

If you are a successful candidate, you will benefit from:

If you have the skills and experience for this opportunity and the ambition to take on this position, please call Francesca for further details or email your CV today.

Contact Francesca at +44 1273 727 930 or fran@stelfoxuk.com

Francesca is a Search expert at Stelfox Pharmaceutical Search covering Europe, UK, North America and Asia.

Contact email address: susan.m.dipaglia@pfizer.com - 11th Jun 2013 [2397]

Pfizer – Clinical Pharmacology Lead - Job ID 982501, location La Jolla, CA

The Clinical Pharmacology Leads (CPLs) are responsible for providing the clinical pharmacology components of clinical plans and provide clinical pharmacology expertise to the project team.

CPLs utilize innovative methods to integrate knowledge of pharmacokinetics, pharmacodynamics, patient characteristics and diseases for rational development strategies and decisions, as well as optimal study designs and dosage regimen selections.

Technical responsibilities

A PhD or MD/PhD in Pharmacology or related scientific field in combination with relevant experience (Level of appointment is determined on experience level).

Preferred Educational Qualifications: A PhD in Pharmacology/Pharmacy/Biological Sciences with hands on quantitative skills and 3-10 years of relevant industry experience.

External website http://www.pfizercareers.com

Contact email address: broseberry@cartermackay.com - 5th Jun 2013 [2396]

Senior Director, PK and ADME

My client is seeking an experienced PhD to lead the development of nonclinical drug metabolism and PK/PD. This position will manage direct reports and work in cross disciplinary project teams. Will be responsible for directing metabolism, PK, TK, and DDI for both large and small molecule compounds. Will cover discovery through POC and into translational. Will also be responsible for dose selection for preclinical studies as well as FIH. Additionally, will oversee preclinical PK/PD data analysis. Will contribute to the preparation of relevant sections of regulatory documents such as IND, IB, NDA, and BLA's. Must have alteast 12 years experience for the Sr Director role and an established track record in PK/PD and related areas as well as success in moving compounds through the nonclinical/preclinical process in preparation for the clinic. Please send questions and resumes to broseberry@cartermackay.com

Contact email address: broseberry@cartermackay.com - 3rd Jun 2013 [2394]

Project Manager, pharmacology and pharmacokinetics (united states)

Seeking a PhD with 5+ years of experience in pharmacokinetics/pharmacology. Must be familiar with working in project teams and in a cross scientific environment. In this role, you have the opportunity to manage projects from discovery through clinical, including late phase clinical. Among the responsibilities in this role, you will manage IND enabling studies, review clinical pahrmacology study protocols, provide clinical trial support, conduct PK modeling and noncompartmental analysis with WinNonLin and NONMEM, and will also write study reports and relevant sections of regulatory documents such as IND and NDA's. The candidate should have extensive knowledge in PK and how compounds are moved through the development process, as well as understanding of areas such as ADME and bioanalysis. A PhD and a minimum of 5 years experience is required. Must also have solid communication skills. Please send CV's or questions to broseberry@cartermackay.com

Contact email address: fatemeh@uri.edu - 2nd Jun 2013 [2393]

Postdoctoral Research Associate, Pharmacokinetics or Drug Metabolism Pharmacokinetics Research Laboratory College of Pharmacy, University of Rhode Island

Pharmacokinetics Research Laboratory within the Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island invites applications for 2-3 postdoctoral research associates. The laboratory is supported by various grants from the National Institutes of Health is located in a brand-new, state-of-the-art research facility.

Major emphasis of the laboratory includes understanding the effect of diabetes or alcohol abuse on drug metabolism and effect. The research will involve characterization of expression and regulation of drug metabolizing enzymes and clinical studies in the area of pharmacokinetics (PK) and pharmacodynamics (PD). Training in PKPD modeling will be provided to suitable candidates. Successful applicant will conduct basic and translational research, attend seminars, teach students, review and write research proposals and compose manuscripts for publication.

Highly motivated individuals with exceptional record of academic achievement and a PhD in pharmacology, drug metabolism, mass spectrometry, pharmaceutical sciences and toxicology, are encouraged to apply. Experience with drug metabolism, drug transport, PKPD modeling, LC-MS/MS, cell culture, genotyping and handling laboratory animals are desirable.

Competitive candidates are expected to have excellent oral and written communication skills, and a strong record of peer reviewed publications. The position is available immediately until a suitable candidate is found. The University of Rhode Island is an AA/EEOD employer and values diversity.

For further information, please contact:

Fatemeh Akhlaghi, PharmD, PhD Professor Biomedical and Pharmaceutical Sciences University of Rhode Island 495A College of pharmacy 7 Greenhouse Road Kingston, RI 02881 USA Phone: (401) 874 9205 Fax: (401) 874 5787 Email: uripkpostdoc@gmail.com

External website http://www.uri.edu/pharmacy/faculty/aps/akhlaghi/

Contact email address: fran@stelfoxuk.com - 1st May 2013 [2392]

Manager Pharmacokinetic Analysis and Reporting, Switzerland

An international pharmaceutical company is looking for an experienced PK scientist to join them in this newly created role.

In this role you will:

You will bring to the role: In return you will receive: If you have the skills and experience for this opportunity and the ambition to take on this position, please call Francesca for further details or email your CV today.

Contact Francesca at +44 1273 727 930 or fran@stelfoxuk.com

Francesca is a Research & Development Search expert at Stelfox Pharmaceutical Search covering Europe, UK, North America and Asia.

Keywords: PK, TK, Pharmacokinetic, Toxicokinetic, outsource, external, vivo, study, CRO, PhD, preclinical, rodent, species, data analysis, Europe, Switzerland, Germany, France, UK, Spain, Netherlands, Sweden, scientist, manager, laboratory, Senior, Principal

Contact email address: smcdonal@usa.ibm.com - 25th Apr 2013 [2391]

Staff Scientist/ Sr. Staff Scientist - PK Modeling Tarrytown, NY # 717BR
www.regeneron.com
If you are looking for an uncommon opportunity -- a chance to join an organization known for its scientific excellence in the research and development of pharmaceuticals -- it's time to consider Regeneron. Regeneron is a fully integrated biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron markets three products in the United States, EYLEA® (aflibercept) Injection, ZALTRAP® (ziv-aflibercept) Injection for Intravenous Infusion, and ARCALYST® (rilonacept) Injection for Subcutaneous Use; ZALTRAP is co-commercialized with Sanofi. Phase 3 studies are in progress with EYLEA in two additional indications and with product candidates sarilumab and REGN727. Regeneron has active research and development programs in many disease areas, including ophthalmology, inflammation, cancer, and hypercholesterolemia.

The Preclinical Pharmacokinetics Group is looking for a Staff Scientist, reporting to a Director, Preclinical Pharmacokinetics. This individual will serve as a key contributor in the Preclinical Pharmacokinetics group. Responsibilities include, but are not limited to:

This position requires a PhD and a minimum of 5-8 years of related experience post PhD. Additional requirements include: Level is commensurate with experience

We offer a competitive compensation and benefits package including stock incentives, 401k with company match as well as the expected health and welfare benefits. Comprehensive relocation benefits are available, as required.

External website http://www.regeneron.com

Contact email address: peter.gennemark@astrazeneca.com - 24th Apr 2013 [2390]

Two PhD/early stage research studentship available in a Marie Curie EU-funded joint project by University of Warwick, AstraZeneca, Fraunhofer-Chalmers Research Centre for Industrial Mathematics, and Swedish University of Agricultural Sciences.

Application deadline: 17th May 2013

Start date: 1st June 2013

Duration: Three years

PROJECT MJC-01: Modelling Dose Response Time Outcome Relationships

The project addresses the development and improvement of methodologies for analyzing dose-response-time data when systemic (plasma) exposure is sparse or lacking. Extending and applying tools and techniques from systems and control theory and in particular nonlinear estimation such as Kalman filtering will be central to developing methodology for this situation. Dose-response-time data analysis (DRT) enables us to more efficiently (quantitatively) analyze and draw conclusions about the underlying rate processes where traditional single-point assessment or area under the response-time curve approach generally fail. Hopefully, this also allows a more robust design tool for future pharmacodynamic experiments in both animals and man. The candidate student should have a strong background (MSc or equivalent) in biological engineering/numerical techniques/computing science/chemical engineering, and life science courses. A track record in pharmacokinetics/dynamics would also be beneficial.

PROJECT MJC-05: Deconvolution in non-linear ordinary differential equations for Quantitive and Systems Pharmacology

The project addresses the development and improvement of methodologies for identifying unknown mathematical relationships in a (nonlinear) pharmacological system where only certain state variables are observed and where data are sparse and noisy. This will lead to an improved understanding of system properties, thus increasing confidence in the selection between prospective compounds and providing more robust design tools for drug discovery. The candidate student should have a strong background in mathematics/computing science, and ideally, have taken life science courses or even pharmacokinetics/dynamics courses.

The successful applicants will receive a stipend of £46,000 per annum over three years.

For online application:

MJC-01 -

http://ec.europa.eu/euraxess/index.cfm/jobs/jobDetails/33847443

MJC-05:

http://ec.europa.eu/euraxess/index.cfm/jobs/jobDetails/33847444

External website http://ec.europa.eu/euraxess/index.cfm/jobs/jobDetails/33847443

Contact email address: broseberry@cartermackay.com - 10th Apr 2013 [2388]

Pharmacokineticist opening!! (United States) My client is a stable, global pharmaceutical company with an excellent group of PK scientists to work with. We are seeking a PhD with experience in clinical PK/PD. Above and beyond the understanding of study design and data analysis, we are seeking someone that is interested in project management and identifying and developing new PK/PD models and working with other groups across multiple disciplines to further the development of PK/PD strategies. Will be the key contributor to PK/PD reports, regulatory filings, and protocols. Will also author in peer reviewed journals. Must have excellent communication skills and the ability to multitask with impeccable work ethic. Required: PhD in pharmacokinetics or related discipline and 0-6 years of experience. Salary and title will be commensurate. Send resumes or questions to broseberry@cartermackay.com (720-328-9526)

Contact email address: jballesteros@viviabiotech.com - 31st Mar 2013 [2382]

Job title: Specialist in Pharmacometry for Personalized Medicine.

Job description: Vivia is pioneering personalizing treatments in blood cancers by evaluating directly in patient samples the pharmacological effect of real-life treatments in eliminating individual patient tumor cells. We have collected a wealth of data on ~40 individual drugs and ~100 drug combination treatments in terms of dose responses in more than 400 patient samples for 4 indications. Candidate will lead the internal effort to analyze this pioneering wealth of data with NOMEN and population models. This analysis is achieving 90% prediction rates enabling launching sales in Q3 2013. This is a key position within the company and we are flexible on the position and salary based on candidates profiles.

Job requirements: PhD in pharmacokinetics, pharmacometrics, or related scientific field Pharmacokinetics and Phamacodynamics. Candidate must have 5-10 years hands-on experience and knowledge of analysis and modeling software (i.e. NONMEM, Phoenix NLME and CTS, Berkeley Madonna) and statistical software (R, S+, etc.). We will use NOMMEN 7.2 and population modeling approaches.

Work Environment: This position is based in Madrid, Spain. It requires significant interactions with internal colleagues from other departments and with external colleagues and consultants. Vivia provides a highly motivational environment where all scientists understand that our personalized medicine test implies that the result of their work every day can mean life or death for an individual cancer patient, a rare employment opportunity that needs to be taken into account very seriously.

Vivia Biotech: Launched in September 2007, Vivia Biotech raised €4 M in seed capital with VC Funds, a record in Span, and has recently raised a new round of €7 M to launch sales of its PM test. Vivia Biotech is a worldwide pioneer in the "screening" and profiling of thousands of drugs on a patient blood samples, thanks to the ExviTech technological platform. This platform, ExviTech, developed originally at USA by an American team moved to Spain to start up Vivia, a pioneer company with international recognition that has been able to take scientific advantage at Spain’s world leadership in terms of altruistic donation of organs and samples for research. Vivia´s team is formed by 28 highly qualified professionals, dedicated to improving the life expectancy and quality of patients with blood cancers.

External website http://www.viviabiotech.com

22nd Mar 2013 [2380]

Scientist, ADME Non-clinical PK/PD

Novartis Institutes for BioMedical Research – Basel, Switzerland

Description:

The Drug Metabolism and Pharmacokinetics (DMPK) Department at the Novartis Institutes for BioMedical Research (NIBR) is looking for an independent degree-qualified scientist with a strong background in ADME/Pharmacokinetics to join their multidisciplinary non-clinical PK/PD group to perform state-of-the-art in-vitro and in-vivo ADME studies. Work location will be Basel, Switzerland.

Developing within the role, you will have the opportunity to take over responsibility for directing in-vitro studies independently. The group’s pool setup allows associates to constantly broaden their portfolio of scientific techniques by contributing to multiple projects across lab boundaries.

Main accountabilities include:

Skills and experience required:

Please apply online at www.novartis.com/careers using Job ID 115022BR.

External website http://www.novartis.com/careers/job-search/index.shtml

22nd Mar 2013 [2378]

Lab Head/Study Director, ADME in non-clinical PK/PD

Novartis Institutes for BioMedical Research – Basel, Switzerland

Description:

The Drug Metabolism and Pharmacokinetics (DMPK) Department within the Novartis Institutes for BioMedical Research (NIBR) in Basel, Switzerland, is recruiting for a PhD-level scientist with experience in in-vivo ADME/PK studies to join their multidisciplinary non-clinical PK/PD team to strengthen the department’s in-vivo capabilities.

As a Study Director, you will deliver quality and timely results on internal and/or outsourced studies and represent those at cross-functional teams and department meetings. As a laboratory head, you will ensure adequate training and supervision of technical staff as well as assessment of their performance (1-2 technicians). The laboratory will focus on ADME/PK, formulation, and/or PK/PD studies in preclinical animal models.

Furthermore, you will represent the DMPK line function in DMPK sub teams and project teams, present findings in teams, document results in internal and external reports/publications and contribute to registration documents.

Skills and experience required:

Please apply online at www.novartis.com/careers using Job ID 114635BR .

External website http://www.novartis.com/careers/job-search/index.shtml

20th Mar 2013 [2376]

Senior Investigator, Clinical PK/PD

Novartis Institutes for BioMedical Research – Basel, Switzerland

Description:

The Drug Metabolism and Pharmacokinetics (DMPK) Department within the Novartis Institutes for BioMedical Research (NIBR) in Basel, Switzerland, is recruiting for a degree-qualified scientist to join their clinical Pharmacokinetics/Pharmacodynamics (PK/PD) team.

In this position you will manage projects (with focus on specific therapeutic areas) and negotiate an optimal PK/PD strategy for early and full development in liaison with appropriate line functions and with Management input as appropriate.

Furthermore, you will be responsible for the PK, PK/PD and M&S component of study protocols, reports, project summaries and development plans within agreed timeframes and which meet regulatory requirements.

Main accountabilities include:

Skills and experience required:

Please apply online at www.novartis.com/careers using Job ID 107244BR

External website http://www.novartis.com/careers

Contact email address: broseberry@cartermackay.com - 19th Mar 2013 [2375]

Director, Clinical Pharmacokinetics (United States)

Seeking a PhD with 8-15 years experience that is looking for a role that will manage across scientific disciplines and have high impact and visibility. Will have hands on scientific involvement and play an active role in the design and analysis of clinical PK studies and data. Will also oversee outsourced studies to CRO partners. Must understand PK modeling data from WinNonLin, NONMEM, etc. Will be expected to contribute to regulatory filings such as IND's and NDA's as well as integrate preclinical and clinical data. This individual will be a scientific leader within the company and play an integral role in the development of drug candidate compounds. For more information or to apply, please send resumes or questions to broseberry@cartermackay.com

15th Mar 2013 [2374]

Principal Scientist, Pharmacometrics

The individual will provide expertise in the area of pharmacometrics (PM) and pharmacokinetic-pharmacodynamics to the project teams and will be responsible for the conduct, summary, and interpretation of pharmacokinetic-pharmacodynamic results and impact on the program. This person will utilize innovative methods to integrate knowledge of PM, pharmacokinetics (PK), pharmacodynamics (PD), patient characteristics and disease for clinical development strategy, clinical trial design, and dosage regimen selection. The ideal candidate in this role will be expected to initiate and support the establishment and integration of modeling and trial simulation, in order to enhance the transition of compounds from preclinical, into man, through Phase III development and regulatory submission.

Major Responsibilities:

Minimum Basic Qualifications: Preferred Qualifications and Experience:

External website http://www.cubist.com/careers/

14th Mar 2013 [2372]

Unilever R&D Vlaardingen is looking for a R&D Manager - Research Scientist PK & ADME

Key responsibilities The primary role of is to serve as representative in multi-disciplinary R&D teams, providing expertise and guidance on all aspects of PK/ADME studies. You will have line management responsibilities.

Main accountabilities You will be responsible for the delivery of assigned projects on time & in full. More specifically, you will:

Key Interfaces You will operate at the interface between our Clinicals group, the Analytical Chemistry Group, Safety/Toxicology and the Nutrition Scientists.

Key skills You are ideally educated with a PhD, preferably with post-doctoral experience, in nutritional physiology, pharmacology or bio-pharmaceutics. You have a scientific background in pharmacokinetics and bioavailability. Knowledge on formulation aspects of solid and liquid dosage forms as well as human PK dose-projections are required. Excellent communication and leadership skills as well as effective interpersonal skills and the ability and experience to work in teams across disciplines and line manage a team of lab technicians is considered as very important.

To apply, you must do so online. For full description see: https://unilever.taleo.net/careersection/external/jobdetail.ftl?job=37041&lang=en&sns_id=linkedin

External website http://https://unilever.taleo.net/careersection/external/jobdetail.ftl?job=37041&lang=en&sns_id=link

10th Mar 2013 [2370]

Expert for Statistical Methods in the Life Sciences (m/f)

Bayer Technology Services GmbH, Leverkusen

Job description

You will be responsible for the development and application of statistical methods on pharmaceutical and biological problems in such areas as pharmacokinetics, bridging and stratification. Your tasks could also include the application of statistical approaches to production and quality issues and the scientific refinement of the respective statistical methods. You will perform scientific analyses of the results and communicate these to the customer. You will also be responsible for supervising students and PhD candidates.

Your qualifications

You are educated to an university degree in the natural sciences with an emphasis on statistics, and preferably have a PhD in this field. Ideally, you will already have experience with the development and application of statistical methods on biological problems. You should also be familiar with optimization issues. You have a sound knowledge of R or Matlab software. Knowledge of Markov chain Monte Carlo methods and SAS would also be advantageous. You enjoy working in a team and have good communication skills. You are proficient in English.

Your application

We offer a performance-based income and very good opportunities for professional and personal development. If you welcome the personal challenge posed by the multiple aspects and responsibility of these tasks, please apply online with your application documents (cover letter, resume, references).

www.myBayerjob.de
Phone +49 214 30 99779
Reference Code: 0000052696

Bayer welcomes applications from all individuals, regardless of racial or ethnic origin, skin color, nationality, religion, philosophy, gender, age, disability, appearance or sexual identity. We are committed to treating all applicants fairly and avoiding discrimination.

External website http://www.systems-biology.com/jobs.html

10th Mar 2013 [2369]

Mechanistic Modelling and Simulation Expert (m/f)

Bayer Technology Services GmbH, Leverkusen
Leveraging Bayer's unique position in Life Sciences: Research at the interface of human, animal and plant health.

Job description

Your tasks at Bayer Technology Services GmbH will lie in the design and creation of mechanistic models in the areas of pharmacokinetics and pharmacodynamics. You will also provide consulting to customers from pharmaceutical research and development on computational life sciences. You will also be responsible for the scientific analysis of the results and their communication to the customer.

Your qualifications

You have a PhD in the natural sciences (pharmacy, biology, chemistry, physics or mathematics) and the relevant knowledge in the fields of pharmacokinetics and pharmacodynamics. You also understand the fundamentals of mechanistic modeling methods. You ideally have several years of experience in the area of disease modeling. You are willing to work in an interdisciplinary team and are fluent in both spoken and written English.

Your application

We offer a performance-based income and very good opportunities for professional and personal development. If you welcome the personal challenge posed by the multiple aspects and responsibility of these tasks, please apply online with your application documents (cover letter, resume, references).

www.myBayerjob.de
Phone +49 214 30 99779
Reference Code: 0000052679

Bayer welcomes applications from all individuals, regardless of racial or ethnic origin, skin color, nationality, religion, philosophy, gender, age, disability, appearance or sexual identity. We are committed to treating all applicants fairly and avoiding discrimination.

External website http://www.systems-biology.com/jobs.html

5th Mar 2013 [2366]

Sr. Scientist/Principal Scientist - PK/PD Modeling & Simulation (Infection) - AstraZeneca (Waltham, MA)

Major responsibilities:

Other Responsibilities

Key Deliverables Minimum Requirements: Please apply online at: http://www.candidatecare.com/srccsh/RTI.home?r=2000019708810&d=astrazeneca.candidatecare.com

External website http://www.candidatecare.com/srccsh/RTI.home?r=2000019708810&d=astrazeneca.candidatecare.com

5th Mar 2013 [2364]

DMPK-NBE Project Representative (m/f)

DMPK Project Representative (m/f) is a strategic and scientific position within DMPK, responsible for the overall nonclinical DMPK contribution to NBE projects from hit optimization up to LCM to fulfill the internal and regulatory requirements.

Your key tasks and responsibilities are:

Provide the scientific leadership in DMPK to drive projects through the different discovery and development stages Represent the DMPK function in the NCD team and the project teams and act as interface between the NCS leader and the DMPK function May assume the role of NCS-Leader, representing the NCD function as core team member in development projects Ensure that the DMPK studies within the given project are conducted according to the agreed timelines and the required quality depending on the stage of the projects Ensure that the DMPK plans/issues are discussed, also dependent on the stage of the molecule, appropriately within the function and that an agreed position is reached before giving feedback outside the function Prepare the DMPK project development plan, in collaboration with all the group experts within the DMPK functions (Exploratory & Development DMPK and Bioanalytics) Provide the DMPK section of regulatory documents and documents used for internal decision making (e.g. DP0 Report, Investigator Brochure, IMPD, IND) Provide adequate support to the NCS-L for DMPK topics in internal and external meetings, Health Authority consultations etc. Provide an integrative PK and immunogenicity assessment to put PK studies into the context of the projects Responsible for the nonclinical and clinical PK and immunogenicity testing strategy May provide TK assessments for exploratory and regulatory safety studies May act as monitor for the outsourced studies within the given project and the given area of expertise Ensure the quality of the outsourced studies and that the generated data/reports meet the applicable international regulatory requirements May provide support for the external opportunity evaluations Manage study timelines and objectives of outsourced studies Oversee the budget for outsourced/internal studies Ensure that the appropriate budget and resources are allocated in PIMS for the development projects

University degree in a pharmacokinetic/chemical-biological field or equivalent training including Ph.D. At least 5 years of professional experience Excellent knowledge of drug development and discovery processes Excellent knowledge of DMPK, related to scientific matters Excellent knowledge of NBE work packages (nonclinical and clinical) General knowledge of the disease area and more in-depth understanding of biology/pharmacology Excellent knowledge of the regulatory requirements Good knowledge of immunogenicity Good understanding of translational sciences (Modeling & Simulation)

External website http://www.merck.de/de/karriere/globale_stellensuche/globale_stellensuche/jobsearch/job-1300150/DMPK

5th Mar 2013 [2363]

DMPK Modeling & Simulation Expert (m/f)

As DMPK Modeling and Simulation Expert (m/f) your key tasks and responsibilities comprise the following:

Contributing to the non-clinical M&S section of regulatory documents and documents used for internal decision making (e.g. DPO Report, Investigator Brochure, IMPD, IND) Integrating knowledge about PK and PD properties of new molecules to support the selection of new compounds Performing more complex human PK predictions and integrating pharmacological data to predict the efficacious human dose and dose scheduling Performing quantitative DDI prediction by applying appropriate models considering the stage of the molecules Ensuring that adequate support for M&S topics in internal and external meetings, HA consultations etc. will be provided to the NCS-L and to the project representatives Ensuring that M&S issues will be discussed appropriately within the function and an agreed position is reached before giving feedback outside the function May acting as an ad hoc member to DPTs, NCS-teams and GPTs Evaluating and implementing new approaches and techniques for M&S May providing TK assessments for exploratory and regulatory safety studies May acting as monitor for studies outsourced within the given project and the given area of expertise Ensuring the quality of outsourced studies and that generated data/reports meet applicable international regulatory requirements May providing support for external opportunity evaluations Managing study timelines and objectives of outsourced studies

University degree in Pharmacokinetic or chemical-biological fields or an equivalent training including Ph.D. Fluent spoken and written English Proficient in communication with impact High managerial skills Good intercultural understanding Strong mature leadership and influencing skills

External website http://www.merckgroup.com/en/careers/global_job_search/global_job_search/jobsearch/job-1204849/DMPK_

Contact email address: jens.quant@boehringer-ingelheim.com - 5th Mar 2013 [2362]

Boehringer Ingelheim RCV Vienna is home to Boehringer Ingelheim’s dedicated drug discovery center for innovative cancer medicines. A team of more than 200 scientists and technicians, with combined expertise in cancer biology and genomics, pharmacology, medicinal chemistry, structural research, high-throughput screening and Discovery ADME, drive our efforts to identify and profile novel oncology drugs. In our Department of Discovery ADME we are looking for a Laboratory Head Pharmacokinetics /Pharmacodynamics.

Your responsibilities:

Your qualifications:

External website http://jobs.boehringer-ingelheim.at/boeviejob.php

4th Mar 2013 [2360]

Join AstraZeneca as a Senior Clinical Pharmacometrician, and you’ll use innovative pharmacometric modelling methods to make decisions that are critical to the future of our business. You’ll be responsible for integrating emerging clinical data with our existing preclinical models, and making sure appropriate feedback is provided. The potential scope is huge – and with innovative new technologies emerging constantly, there’s never been a better time to come aboard.

AstraZeneca – Health Connects Us All

As one of the world's leading pharmaceutical companies, our business is focused on providing innovative, effective medicines that make a real difference in important areas of healthcare. At AstraZeneca, innovation is about more than just research. We aim to stimulate continued creativity throughout our organisation by maintaining a culture in which our people feel valued, energised and rewarded for their ideas and contribution to our success - ideas which can make a difference in all aspects of our business. And we support and encourage our people in discovering their own potential, through excellent learning and development opportunities that are available to them throughout their careers.

As a Senior Clinical Pharmacometrician your skills and qualifications will ideally include:

As a Senior Clinical Pharmacometrician your main responsibilities will involve: What we will be looking for in you:

We’ll need to see extensive experience gained in a variety of disciplines, including pharmacology, pharmaceutical sciences, biostatistics, medicine, mathematics, physiology or engineering.

External website http://gs.globalsuccessor.com/fe/tpl_astrazenecav2.asp?newms=jj&id=59262&----JOB-PREVIEW-MODE----

Contact email address: fran@stelfoxuk.com - 26th Feb 2013 [2358]

Senior Principal Scientist Pharmacokinetics NBE, Germany

This is an exciting opportunity for an experienced Pharmacokineticist to join a market leading and innovative global pharmaceutical company. This position is based in the South of Germany.

In this challenging role will:

You will bring to the role: In return you will receive: If you have the skills and experience for this opportunity and the ambition to take on this position, please call Francesca for further details or email your CV today.

Contact Francesca at +44 1273 727 930 or fran@stelfoxuk.com

Francesca is a Research & Development Search expert at Stelfox Pharmaceutical Search covering Europe, UK, North America and Asia.

External website http://stelfox.broadbeantech.com/

Contact email address: fran@stelfoxuk.com - 26th Feb 2013 [2357]

Principal Scientist Pharmacokinetics NBE, Germany

This is an exciting opportunity for an experienced Pharmacokineticist to join a market leading and innovative global pharmaceutical company. This position is based in the South of Germany.

In this challenging role will:

You will bring to the role: In return you will receive: If you have the skills and experience for this opportunity and the ambition to take on this position, please call Francesca for further details or email your CV today.

Contact Francesca at +44 1273 727 930 or fran@stelfoxuk.com

Francesca is a Research & Development Search expert at Stelfox Pharmaceutical Search covering Europe, UK, North America and Asia.

External website http://stelfox.broadbeantech.com/

Contact email address: fran@stelfoxuk.com - 26th Feb 2013 [2356]

Senior Scientist Pharmacokinetics NBE, Germany

This is an exciting opportunity for an experienced Pharmacokineticist to join a market leading and innovative global pharmaceutical company. This position is based in the South of Germany.

In this challenging role will:

You will bring to the role: In return you will receive: If you have the skills and experience for this opportunity and the ambition to take on this position, please call Francesca for further details or email your CV today.

Contact Francesca at +44 1273 727 930 or fran@stelfoxuk.com

Francesca is a Research & Development Search expert at Stelfox Pharmaceutical Search covering Europe, UK, North America and Asia.

External website http://stelfox.broadbeantech.com/

Contact email address: shahr10@gene.com - 25th Feb 2013 [2355]

The Clinical Pharmacology Department at Genentech, Inc. is seeking a Ph.D. level Senior Scientist who is driven to understand the clinical pharmacokinetics and pharmacodynamics of novel drug candidates in the area of Oncology. This individual will be responsible for the clinical PKPD activities of Biologics, Antibody Drug Conjugates and/or Small Molecules in clinical development. This person will have responsibility for the Clinical Pharmacology strategy in order to ensure that appropriate dose/route/schedule decisions are made using the state of the art modeling and simulation strategies that are aligned with project needs. This will be accomplished by working in close partnership with Clinicians, Biostatisticians, Clinicians and project teams. Responsibilities will include planning and reviewing study designs, analysis plans, data analysis, interpretation of PK/PD as well as planning, implementation and organization of regulatory filings (worldwide) and presentation of data at cross-functional teams, department meetings, conferences and regulatory meetings (worldwide). Additionally this individual will also be directly involved in leading project sub-teams and representing the function at cross-functional project teams. Relevant experience and demonstrated impact on drug development is expected and experience with Biologics is highly desired. In addition, experience in the preparation of regulatory interactions and good knowledge of GCP and regulatory guidelines is highly desirable. Leadership abilities are a plus.

The candidate must have excellent communication skills, the ability to work independently and the ability to work effectively on interdepartmental project teams. Familiarity with quantitative approaches in drug development, working knowledge of modeling software (NONMEM, ADAPT II and WinNonlin) and the ability to plan, organize, and critically assess and/or perform PK/PD data analyses are essential

A Ph.D. or equivalent in Pharmacokinetics, Pharmaceutical Sciences, Biomedical Engineering or related discipline with >10 yrs years of industry and/or related post-doctoral Clinical Pharmacology experience are required

External website http://www.gene.com/careers

Contact email address: cwto@novonordisk.com - 23rd Feb 2013 [2354]

Temporary Modelling Scientist Position available at Novo Nordisk A/S

Do you want to conduct PK/PD and exposure-response analyses to support the development of new drugs at Novo Nordisk in a one year temporary position?

About the department: The Quantitative Clinical Pharmacology department supports the entire Novo Nordisk development portfolio with model-based analyses from first in human studies to registration. You will be part of a diverse team of dedicated modelling and clinical pharmacology scientists in our R&D Global Development organisation.

The Job:
As Modelling Scientist you will have an important role in the development of new drugs at Novo Nordisk, taking part in designing, analysing, interpreting, communicating and reporting quantitative clinical pharmacology information (e.g. population PK/PD and exposure-response analyses) at all stages of clinical drug development. You will be part of multidisciplinary project teams where you will be responsible for developing modelling analysis plans for the project and follow them to completion.

Qualifications:
You hold a university degree in a relevant area (Statistics, Engineering, Pharmacy or other), preferably with a supplementary Ph.D. You are fluent in English both orally and written. You have a strong background in pharmacokinetics, statistics and/or quantitative clinical pharmacology analyses and have hands-on experience using S-PLUS/R and/or NONMEM. You are innovative with a high degree of independence, result and quality oriented, and thrive in a continuously changing environment with tight deadlines. You appreciate an informal atmosphere and act as a dedicated team player. As your colleagues will have different academic backgrounds, good presentation, communication and negotiation skills are essential.

At Novo Nordisk, we strive for excellence. As a world leader in diabetes care and a major player in haemostasis management, growth hormone therapy and hormone replacement therapy, we offer our employees opportunities for continuous growth.

Contact: For further information, please contact Christoffer Wenzel Tornøe at +45 3075 8193.

Deadline: 17 March 2013.

External website http://novonordisk.com/careers/job_section/current_jobs.asp?jobid=12436BR&lCountry=

Contact email address: broseberry@cartermackay.com - 21st Feb 2013 [2353]

Associate Director, Pharmacology (United States)

seeking a PhD with 7+ years experience in developing in vivo and in vitro models for compound screening. Will investigate mechanism of action and support clinical results for efficacy. review study design and evaluate data from in vivo and in vitro nonclinical pharmacology studies. Will also be expected to identify pharmacological effects that may produce AE in clinical trials. Must have experience in nonclinical sections of NDA\\\'s and IND\\\'s. Will extrapolate data from preclinical to human dose projection and review clinical protocols up to phase II, as well as PK, drug interaction, and ADME. Will attend meetings with FDA and present research findings at meetings and conferences. Great opportunity with an established pharma client. please send resumes or questions to broseberry@cartermackay.com

19th Feb 2013 [2352]

Shire is currently seeking a Sr Director of Pharmacokinetics to join our Clinical Pharmacology team in supporting drug development project teams across all therapeutic areas and all stages of Development. You will also provide clinical PK/PD expertise to support the development, registration and commercialization of Shire’s products from before first-in-human studies and throughout the product lifecycle.

You will have an excellent track record in a similar position within either a pharmaceutical company or a CRO.

You will design clinical pharmacology/PK programs to support the development, registration and commercialization of Shire’s products and ensure programs comply with regulatory authority and legal requirements.

You will collaborate internally and externally as necessary to agree programs of work and budgets.

You will use your expertise to select suitable Contract Research Organisations (CROs) and academic centers to carry out programs of work and to establish collaborations with key consultants. You will also be responsible for the ongoing monitoring of those partners.

You will agree on detailed study protocols with contractors and monitor programs of work to ensure compliance with agreed protocols, quality standards and timelines as well as review data in a timely manner and amend protocols as necessary to achieve best outcome.

Together with the study team, you will be responsible for ensuring a high quality report, suitable for regulatory submission, is produced for each study and involve other internal and external specialists as necessary to interpret findings and assess relevance for use in man.

You will provide clinical PK and human drug metabolism expertise to Project Teams and Shire management across projects.

You will provide the clinical pharmacokinetics and pharmacodynamics expertise and support required for preparation of Investigator Brochures, Clinical Trials Applications, Marketing Applications, regulatory meetings, and responses to regulatory questions. You will agree the clinical pharmacology documentation plan for each submission, including timelines and how the work is to be resourced, with the Project Team and VP Clinical Pharmacology

EDUCATION & EXPERIENCE REQUIREMENTS:

Shire's Brave culture offers employees with diverse backgrounds the opportunity to enable those with life altering conditions to lead better lives.

If you wish to apply for this position, please send your C.V. to: Peter Murphy, Internal Recruiter, Shire Pharmaceuticals, Chineham, Basingstoke, Hampshire, RG24 8EP. (e-mail: pmurphy-c@shire.com; Tel: +44-(0)1256- 894076; Fax: +44-(0)1256- 894718)

19th Feb 2013 [2351]

The TI Pharma Mechanism-Based PKPD Modeling Platform is a public-private partnership focused on the development of a mechanism-based PKPD and Systems Pharmacology models for rational drug discovery and development. After completion of the successful first phase, the platform is now entering the second phase of 5 years. PKPD platform 2.0 comprises of 7 Academic and Industrial partners and is coordinated by the Leiden Academic Centre for Drug Research (LACDR) at Leiden University (The Netherlands). There are now several positions available for postdoctoral fellows. Key requirements are a strong background in advanced mathematical and statistical modeling and data analysis (ideally with experience of application in biomedical sciences), a track record of scientific innovation and a real desire to be at the forefront of the development of novel concepts in translational PKPD the emerging discipline of Systems Pharmacology. For more information, contact j.p.poels@lacdr.leidenuniv.nl

Contact email address: yjeong@uic.edu - 15th Feb 2013 [2350]

The Department of Pharmacy Practice at the University of Illinois at Chicago is seeking a postdoctoral research associate to work on a preclinical drug development project. A PhD degree in drug metabolism and pharmacokinetics (or related field) and experience in analytical chemistry (HPLC/mass spectrometry) are required. The project involves experiments in the areas of preclinical pharmacokinetics: drug metabolism in microsomes and hepatocytes, metabolite identification, plasma protein binding, CYP induction/inhibition, and in vivo pharmacokinetic studies in mice and rats. The candidate will also have an opportunity to get involved in different projects in Jeong lab (http://openwetware.org/wiki/Jeong_lab). For fullest consideration, applicants should send a CV and a list of three references by March 31, 2013 to: Young Jeong at yjeong@uic.edu.

External website http://openwetware.org/wiki/Jeong_lab

14th Feb 2013 [2349]

The role: Associate Director/Director Clinical Pharmacometrician - AstraZeneca - Wilmington, DE

This is a scientific role within our Clinical Pharmacology & Pharmacometrics group which is involved in candidate drug (CD) selection and in all clinical phases of the product development including registration and commercialization. We are looking for an individual to fill the role of a Director/ Associate Director in the US.

In the implementation of Model Based Drug Development (MBDD), the Director will work closely together with other modeling skills (such as preclinical PKPD scientists, statistical modelers etc ) to develop MBDD plans for disease area related as well as compound related modeling. The Director will develop pharmaco-statistical models including disease models, exposure response models, biomarker - efficacy models etc. The Director will work as a partner in multi-disciplinary development teams by providing MBDD expertise.

The Director will, together with statisticians, have the overall accountability for the MBDD plan. We will also look to this individual to collaborate externally by publishing their work, building relationships with academic institutions and building their expertise by networking with individuals in the pharmacometric field. Individuals in the senior role will also be called upon to coach less senior staff in their modeling work.

Minimum experience

For the Associate Director role, candidates will have a doctorate degree (preferred) but a Master\'s degree and other relevant academic training is acceptable. Candidates should have demonstrated expertise in pharmacometrics (PM) and strong quantitative skills (e.g. experience in mechanistic modeling/systems pharmacology, quantitative translational scaling, literature meta-analyses, population modeling)

For the Director role, a doctorate degree with demonstrated expertise in pharmacometrics and strong quantitative skills (e.g. experience in mechanistic modeling/systems pharmacology, quantitative translational scaling, literature meta-analyses, population modeling) is required. The Director\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\'s experience (>10 years) may have been gained in a variety disciplines including pharmacology, pharmaceutical sciences, biostatistics, medicine, mathematics, physiology, or engineering.. A minimum of 5 years pharmaceutical industry experience, specifically contributing to pharmacometrics aspects of clinical drug development, is essential. As is an in-depth knowledge of advanced PK and PK/PD, a proficiency with pharmacometric/statistical software tools such as NONMEM, R, SAS, S-Plus, Matlab, Berkeley Madonna, a knowledge of FDA/ICH requirements for drug registration, knowledge of Bayesian methods and Monte-Carlo simulation, PK and PD drug interactions, in vivo/in vitro models, biopharmaceutics and the ability to understand, and implement all aspects of pharmacometrics needs across a variety of disease areas.

External website http://jobs.astrazeneca.com/jobs/22159

Contact email address: nolin@pitt.edu - 13th Feb 2013 [2348]

UNIV OF PITTSBURGH SEEKING PHARMACOMETRICS FACULTY MEMBER

The University of Pittsburgh School of Pharmacy (Pittsburgh, PA, USA) is seeking a highly motivated, innovative, and dedicated faculty member with expertise in pharmacometrics, including clinical pharmacokinetic/pharmacodynamic modeling, population pharmacokinetic modeling or modeling and simulation of clinical trials. Individuals focused on the application of quantitative pharmacology or pharmacometric concepts and techniques to therapeutics will have preference. The candidate must be an investigator with demonstrated training, interest and commitment to pharmacometrics research or its application. This non-tenure position is at the Assistant, Associate, or Professor level, commensurate with experience.

Interested individuals should submit inquiries to Tom Nolin at TEL 1-412-624-4683 or Email nolin@pitt.edu

The University of Pittsburgh is an Affirmative Action, Equal Opportunity Employer.

12th Feb 2013 [2347]

Principal Scientist - PK/PD Modeling & Simulation (Oncology)- AstraZeneca - Waltham, MA

At AstraZeneca, our aim is to tackle illness and disease as effectively as possible. Through our R&D pipeline of life-changing medicines, we\\\'re able to offer hope to millions around the world. And innovation is essential to our job. Our strategy includes a substantial application of Predictive Sciences, which help us to deliver drugs that tackle illness and disease even more effectively. The model-based approach is applied to the whole drug development process, and this includes developing a quantitative understanding of the biological hypothesis of drug action on the disease target. An understanding of pre-clinical quantitative pharmacology underpins our human predictions of dose, dose schedule, and therapeutic index and these predictions are critical to drug projects.

The Oncology Innovative Medicines unit (iMED) has an exciting opportunity for an experienced Modeling and Simulation (M&S) scientist to join a vibrant global team. The individual will be embedded into the Oncology research group, working closely with scientists in Biology, Translation, Safety and other modelers. The successful candidate will have excellent problem solving, organizational, and documentation skills, in addition to strong oral and written communication skills. This role requires the ability to thrive in a team-based, multidisciplinary, fast-paced research environment.

Minimum Requirements:

* PhD or equivalent degree in a discipline with a significant component of Modeling & Simulation, such as systems biology, quantitative pharmacology, pharmacometrics, chemical engineering, physics, or applied mathematics, with at least 5 years of relevant industry experience in Modeling & Simulation, ideally in preclinical/translational setting, or an MS degree with at least 10 years of relevant industry experience. * Experience in project-facing role at pharmaceutical R&D. * Comprehensive understanding of DMPK and pharmacology/safety aspects of drug discovery and development. * Track record of supporting PK, PKPD and TKPD aspects of projects, with a delivery focus and ability to meet timelines to pre-specified quality and cost. * Specialist in tools such as WinNonLin/Phoenix NLME, NonMem, Berkeley Madonna, MATLAB, and SimCYP * Experience in project-facing role at pharmaceutical R&D. * Comprehensive understanding of DMPK and pharmacology/safety aspects of drug discovery and development. * Track record of supporting PK, PKPD and TKPD aspects of projects, with a delivery focus and ability to meet timelines to pre-specified quality and cost. * Specialist in tools such as WinNonLin/Phoenix NLME, NonMem, Berkeley Madonna, MATLAB, and SimCYP.

External website http://www.candidatecare.com/srccsh/RTI.home?r=2000019435810&d=astrazeneca.candidatecare.com

Contact email address: broseberry@cartermackay.com - 4th Feb 2013 [2345]

Director, In Vivo Pharmacology--CNS/Pain--northeast US location.

Seeking a PhD with 10+ years experience in in vivo pharmacology, specifcally in the area of discovery through IND. Majority of focus will be on pain models and the evaluation of chemical properties, PK, and ADME information. Will work in multiple cross functional teams and lead a group of pharmacology scientists. Will be expected to support team objectives and bring a full understanding of the scientific basis of pharmacology experiments to project teams. Must have experience in evaluating, establishing, and managing successful drug discovery projects as well as moving compounds into development candidates. If interested, and for more information, send CV/inquiries to broseberry@cartermackay.com

Contact email address: info@greylock-recruiting.com - 4th Feb 2013 [2344]

We are currently seeking a leader to head nonclinical PK/PD for large molecules (and a few small molecules). The incumbent should possess the following:

External website http://www.greylock-recruiting.com

31st Jan 2013 [2341]

COMPANY: Founded in 1974, Apotex Inc. is the largest Canadian-owned pharmaceutical company. From its 2 employees, 5,000 square foot beginning, the company has grown to employ over 6,800 people in research, development, manufacturing and distribution facilities world-wide.

POSITION: Scientific Leader (Supervisor), Pharmacokinetics

LOCATION: Toronto, ON Canada

JOB SUMMARY: Reporting to and working with the Manager, Pharmacokinetics, the Scientific Leader, Pharmacokinetics is responsible for the management of work and supervising the operation of the Pharmacokinetics department. In this role, the incumbent interacts cross-functionally with other management members within the BioClinical Development Division to ensure that all biostudy projects and related work is properly planned and managed. The incumbent ensures that departmental administration and work is properly assigned and completed, and that all work is conducted in full compliance with established Apotex Inc. Policies, Standard Operating Procedures and relevant Regulatory Guidance(s). In addition, the Scientific Leader, Pharmacokinetics is working together with the Manager, Pharmacokinetics on recruitment, hiring and , coaching of the departmental staff, and is directly responsible for performance management of the relevant employees in the Pharmacokinetics Department.

EDUCATIONAL REQUIREMENTS/EXPERIENCE:

**For more information please visit our website

External website http://https://careersen-apotex.icims.com/jobs/2511/job

29th Jan 2013 [2340]

Put your passion to work at Seattle Genetics

The strength of the Seattle Genetics team resides in our collective commitment to patient care, individual excellence and teamwork.

Pharmacokineticist/Sr. Pharmacokineticist Location: Bothell, Washington Job Code: 1301TH-01

Description Seattle Genetics is seeking a bright and motivated pharmacokineticist to join our Clinical Pharmacology Department

Responsibilities

Requirements

Seattle Genetics is an equal opportunity employer.

If you are interested, please apply through the Seattle Genetics website:

http://ch.tbe.taleo.net/CH09/ats/careers/requisition.jsp?org=SEAGEN&cws=1&rid=1148

External website http://ch.tbe.taleo.net/CH09/ats/careers/requisition.jsp?org=SEAGEN&cws=1&rid=1148

Contact email address: broseberry@cartermackay.com - 22nd Jan 2013 [2339]

Pharmacometrician opening--Associate Director level--contact broseberry@cartermackay.com

Summary of Responsibilities

For more information, please send CV to broseberry@cartermackay.com
Contact email address: telder@greylock-recruiting.com - 14th Jan 2013 [2338]

UNITED STATES OPPORTUNITY! We are working on an Associate Director or Director of Pharmacometrics located in the US! If you have experience with NONMEM, population PK, NDA/BLA experience, experience at a CRO is a big plus. Let us know! This exciting opportunity is with a well establshed pharma company that has one of the strongest PK/Clin Pharm teams in the industry. Be a part of it!

External website http://www.greylock-recruiting.com

10th Jan 2013 [2337]

Company: Sanofi, Boston Hub Associate Director, Clinical Pharmacokinetics

The Associate Director, Clinical Pharmacokinetics will provide strong scientific leadership within the Drug Metabolism and Pharmacokinetics (DMPK) function in support of the portfolio of the Sanofi Boston R&D Hub.

In this role the Associate Director will serve as a primary source of scientific support for the design, analysis, reporting, and presentation of pharmacokinetic and pharmacodynamic modeling and simulation initiatives. The individual will be supporting early development by providing pharmacokinetic support and representing the DMPK organization on integrated project teams across preclinical and clinical development through proof of concept. Responsibilities will include prediction of human dose, pharmacokinetics and therapeutic window to support development decision making and first in human clinical trials. The individual will collaborate with the clinical team to design pharmacokinetic components in various clinical study designs including first-in-human and drug-drug interaction studies. In addition, the individual will contribute to pharmacokinetic analysis, interpretation and reporting of pharmacokinetic results from clinical trials, and will support a quantitative model-based drug development approach.

Qualifications Requirements

Job: Research And Development Primary Location: United States-Massachusetts-Waltham

External website http://www.genzyme.com/Careers/Job-Search.aspx

Contact email address: jon.gibbs@parexel.com - 7th Jan 2013 [2336]

Company: PAREXEL Job Title: Principal Pharmacokinetic Scientist Department: Scientific Services – Clinical PK/PD and Pharmacometrics Location: UK, Uxbridge Essential Function Primary role of the PK Scientist

Skills: Education:

External website http://sh.webhire.com/servlet/av/jd?ai=206&ji=2641743&sn=I

Contact email address: fairmand@medimmune.com - 21st Dec 2012 [2334]

MedImmune is looking to expand its predictive science group and is recruiting a Clinical Pharmacokineticist in its Cambridge UK facility.

Reporting to David Fairman within Balaji Agoram\\\'s Clinical pharmacology and DMPK department the Clinical Pharmacokineticist will be responsible for all aspects of PK/PD-related support for bio therapeutic products.

The Clinical Pharmacokineticist functions as the Global Clinical Pharmacology and DMPK project leader and team representative for biotherapeutic projects at all stages of research and development - from discovery through to BLA.

The scientist will be responsible for all aspects of PK/PD-related support for bio therapeutic products, including design of preclinical and clinical studies, modeling and simulation analysis, trial simulation, and reporting (including GLP data) and communication of data in regulatory documents and meetings.

The successful candidate\\\'s previous experience will include:

Strong PK/PD experience in the execution and application of modeling and simulation is essential. Preferably within an industrial setting but a highly relevant academic lab will be considered. Demonstrate a strong understanding of the drug development process. Evidence of leading study designs in collaboration with clinical or preclinical colleagues would be a significant advantage. Modeling and simulation experience including utilization of packages such as NONMEM, Berkeley Madonna, S-plus and Matlab. Demonstrable team working skills with a track record of delivery and communication of high quality modelling output.

Education: Your experience will be built on a BSc or equivalent as minimum with MSc or PhD in a relevant field preferred

Please see the link for full description and application details.

External website http://www.candidatecare.com/srccsh/RTI.home?r=2000018146110&d=medimmune.candidatecare.com

Contact email address: mohammed.ullah@roche.com - 14th Dec 2012 [2333]

Scientist Drug Transport - Roche

The Position: This challenging position within Early and investigative Drug Dispositions and Safety (EiDDS) includes the following responsibilities:

Provide support to discovery and development projects to elucidate drug transporter processes related to oral absorption, tissue distribution, renal and biliary elimination, as well as the potential for transporter-related drug-drug interactions Responsibility for the design and conduct of tailored in-vitro drug transport studies with technical support of other co-workers within the same group to assess new chemical entities for their potential as substrates or inhibitors of different drug transport proteins Data evaluation, all study-related documentation, communication, and data reporting in regulatory reports or other documents Keeping up to date on the latest developments in the area of drug transport; development of new, innovative in-vitro tools and methods to address questions related to drug safety and relevant for clinical candidate selection; publication of results is highly encouraged Maintain open channels of communication with other disciplines such as screening, enzymology, drug metabolism and bioanalytics. There will also be a need to collaborate with partner groups within NCS, such as discovery and development project leaders, modeling and simulation and clinical pharmacology, supporting/addressing questions with respect to drug transport

Who you are: You’re someone who wants to influence your own development. You’re looking for a company where you have the opportunity to pursue your interests across functions and geographies. Where a job title is not considered the final definition of who you are, but the starting point. Your qualifications will include: PhD or equivalent in pharmacy, biology or a related field with post-doctoral training or previous relevant experience in the pharmaceutical or biotech industry (3-5 years) In-depth knowledge of and practical experience with drug transport proteins in the context of drug research and development; strong background in cell biology and practical experience with cell-based assays Knowledge of pharmacokinetics is an asset High motivation and commitment to work in a team; strive to develop into new areas and expand your existing capabilities; flexible, efficient and used to deliver on tight time lines. Familiarity with standard hard- and software (Windows, Office, and software data evaluation applications), electronic sample management applications, literature searches and kinetic evaluation are expected Excellent command of written and spoken English is required

External website http://careers.roche.com/en/jobs/SWITZERLAND/RESEARCH/2613854356/Scientist-Drug-Transport.html

Last update: Fri 14 Jun 2013 08:51:49 am

Copyright © 2003-2013 David Bourne (david@boomer.org)