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The following message was posted to: PharmPK
I would like to ask PK scientist who has some experience in quantification
of Topiramate in human plasma after oral administration of topiramate
tablets.
Some reports with GC method are available but I am interested in HPLC
methods. I would like to receive comments on invitro dissolution
characteristics also.
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The following message was posted to: PharmPK
We routinely measure plasma topiramate concentrations in patients with
epilepsy under topiramate therapy. We use LC/MS after plasma protein
precipitation. Chromatographic time is 3 min , the limit of detection is
about 50 ng/ml and the linearity is good up to 20 ug/ml.
We partecipate in the external quality control scheme for TDM (eathcontrol
scheme, CBS,Ltd., Cardiff) with good results. Apparenlty (from the quality
control sheet) other two laboratories in the scheme measure plasma
topiramate by HPLC.
Feel free to contact me directly if you need further information.
Roberto Riva M.D., Dept. of Neurological Sciences, University of Bologna,
Italy
riva.-a-.neuro.unibo.it
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)