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The following message was posted to: PharmPK
Subject: Bioavailability of quaternary ammonium
Question: recently i am going through the PK and
bioavailability of quaternary ammonium compounds.
i got very less oral bioavailability. ALT711,a
molecule from ALTEON having AGE breaker activity has
completed PHASE-II A clinical trial successfully,
although it is a quaternary ammonium compound. They
are giving 8mg/tab bid. so how far it is bioavailable?
Is there any way to increase its bioavailability?
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