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We would appreciate it if someone could give us suggestions regarding
some recent problems with our isolated perfused rat kidney system.
We have established a stable isolated perfused rat kidney preparation
and have used it successfully for many years using the following
brands of bovine serum albumin:
Pentex Fraction V
Miles Inc., IL, USA
Sigma=E2 Fraction V
True Cohn Fraction V
However, with the same products purchased after June and July this
year, the perfusions are unacceptable - notably, Glomerular
=46iltration Rate is unstable and much lower than it has been in the
Have any other groups experienced problems with new batches of bovine
albumin? We suspect that there might be different handling
(preparation) due to the BSE (Mad Cow) or Foot & Mouth problems in
Europe., but have not had any useful information from suppliers.
Also, does anyone know of alternative suppliers that we could try. We
normally purchase 1 kg at a time.
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