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The following message was posted to: PharmPK
LogP is an indicative of lipophilicity of compound. For a compound
to have protein binding it should be lipophilic. larger the
lipophilicity larger will be the extent of protein binding. Now the
protein binding has direct relationship with Vd as follows
Vd= Vp+Vt * Fp/ Ft where Fp & Ft are fraction of free drug in
plasma and tissue compartment respectively.
So if due to high LogP drug binds to plasma protein free drug
present will reduce and so also the volume of distribution. In
contrary to this if due to very high LogP ( or due to specific
affinity ) drug binds to tissue protein , the volume of distribution
will increases . ( eg. thiopental, cloroquine).
This is the generalized correlation based on QSAR. I hope this will be of use .
Torrent Research Centre.
Vaseline Lipguard Keep Smiling
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