Back to the Top
What basic protocole would you suggest we use to get a first estimation
of a near-optimal dosing regimen in mice for a new anti-infective agent
on which we have little information? We will use the dosing regimen for
evaluation of efficacy in infected mice.
Back to the Top
The following message was posted to: PharmPK
"Mario Thomas (by way of David_Bourne)" wrote:
> PharmPK - Discussions about Pharmacokinetics
> Pharmacodynamics and related topics
> What basic protocole would you suggest we use to get a first estimation
> of a near-optimal dosing regimen in mice for a new anti-infective agent
> on which we have little information? We will use the dosing regimen for
> evaluation of efficacy in infected mice.
Use whatever info you have from in vitro studies of the
anti-infective agent to establish a likely in vivo target conc e.g.
at least the MIC. Try to use the unbound in vitro concentration and
this will then predict a reasonable starting place for an unbound
conc in vivo.
Do some pilot PK studies in the mice to discover the doses needed to
achieve/maintain the target conc.
Then do your effectiveness studies with this regimen. Establishing an
optimal regimen will necessarily involve further experimental studies
in vivo using different regimens.
Nick Holford, Divn Pharmacology & Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
email:n.holford.at.auckland.ac.nz tel:+64(9)373-7599x6730 fax:373-7556
PharmPK Discussion List Archive Index page
Copyright 1995-2010 David W. A. Bourne (email@example.com)