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Dear Colleagues,
I have recently started to study a few novel
compounds'pharmacokinetics in rats. I have found a Vss of about 97.0
mL for this compound in rats after oral and 96.0 mL after iv-bolus
dosing, using winnolin non-compartmental method of analysis. These
numbers are for rats weighing on average about 270 grams. Can anyone
inform as to whether these numbers mean a high or a low Vd drug?
Also, can anyone refer me to a good reference regarding rat
physiological parameters?
Thank you all.
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The following message was posted to: PharmPK
I would say that is a large Vd.. the blood volume of a 250g rat is
approximately 22.5 mL, Liver is about 15ml....
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The following message was posted to: PharmPK
Panteha,
You might find the following link to the Center of Applied Pharmacokinetic
Research at the University of Manchester quite helpful. Physiological
parameter values are provided for rats and other species.
http://www.capkr.man.ac.uk/CAPKR/Science/Physiol_Params/physparm.htm
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The following message was posted to: PharmPK
Dear Panteha,
I would say a Vdss of 0.36L/kg is a low distribution volume in the rat,
because lower than the Total Body Water for the rat (0.6-0.7 L/kg).
A medium Vdss would be : TBW < x < 5 L/kg
A high Vdss would be between 5 and 100 L/Kg.
For physiological parameters in various species see : Brian Davies and Tim
Morris, Pharmaceutical Research, Vol.10, No.7, 1993. Physiological
Parameters in Laboratory Animals and Humans.
Hope it helps.
Pascal ESPIE
Product Safety and Metabolism department
UCB Pharma (Belgium)
Mail : pascal.espie.aaa.ucb-group.com
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