PharmPK Discussion - Is there a drug that may postpone dialysis?

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On 25 Jan 2001 at 22:59:54, "Katarina Ilic" (kettyilic.aaa.hotmail.com) sent the message


The following message was posted to: PharmPK

Dear colleagues,

I will greatly appreciate if someone could give me the answer if
there is a drug that in case of disturbed renal function may increase
renal blood flow and postpone dialysis? Also what are the recommended
doses?

Thank you in advance.

Yours sincerely,

Dr. Katarina Ilic
Faculty of Pharmacy
Dept. of Pharmacology,
P.O.Box 146,
Vojvode Stepe, 450
11 000 Belgrade, Yugoslavia

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On 28 Jan 2001 at 22:02:52, ml11439.aaa.goodnet.com sent the message


The following message was posted to: PharmPK

Dr. Ilic,

     Low dose dopamine infusions (3-5 ug/kg/min) are frequently
used in the management of acute renal failure in hospitalized
patients. Dopamine is a selective renal vasodilator at low doses
which increases urine ouput.

     Furosemide is also commonly used in the treatment of acute
renal failure, where it may convert oliguric ARF to nonoliguric
ARF. Furosemide may also benefit the course of ARF by flushing
casts and cellular debris from the renal tubules. The osmotic
diuretic mannitol is also used in ARF.

     Investigational agents used in ARF include atrial natriuretic
peptide, which by selectively dilating the afferent arteriole, can
cause an increase in GFR and natriuresis. Other agents being
investigated for the treatment of ARF include endothelins and
insulin-like growth factor-1.

                                        Mike Leibold, PharmD, RPh
                                        ML11439.-a-.goodnet.com

Reference:
1) Conn's Current Therapy 2001

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