PharmPK Discussion - Metabolism of glyburide and glipizide

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On 12 Nov 2001 at 10:50:29, "Patel, Loshani [JACZA]" (lpatel2.aaa.jacza.jnj.com) sent the message


Is chlorpheniramine and/or dexchlorpheniramine metabolised extensively by
the cytochrome P450 system?
If so, then which enzyme system does it act in?
I am specifically looking for drug interaction information between these
antihistamines and CYP3A4 substrates.

Many Thanks
Loshani

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