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The following message was posted to: PharmPK
Hello Sunil:
You might be able to use the bile duct microdialysis probe to study the
drug and its metabolites. As far as studying bile components, you would
have to keep in mind that we add bile salts to the microdialysis perfusion
fluid. With this technique, you have to perfuse with a solution that is
isotonic with the tissue or medium surrounding the probe. Hence, you use
artificial CSF when placing a probe in the brain or intrathecal space, you
use Ringer's solution when placing a probe in a blood vessel or subcut.
tissue, and you use a saline solution supplemented with bile salts when
dialyzing the bile flow. You might be looking for very minor changes
(increase or decrease) in bile salts reflecting the change in bile
composition.
We are not currently doing bile duct microdialysis in our labs -- we had
done this quite intensely for several years but are now doing other
projects. You will find several related papers on the website for our
research newsletter at http://www.currentseparations.com going back about 4
to 5 years. However, if you find an opportunity to pay us a visit, we'll
be happy to talk to you and show you what we are doing in microdialysis, as
well as our DMPK projects. We do have an industrial post-doc program and
have also welcomed people for sabbatical studies when our interests
coincide. So, if you're thinking along the lines of more than a quick
visit, we can talk more. Contact me at: candice.aaa.bioanalytical.com
Best Regards,
Candice Kissinger
Bioanalytical Systems Inc.
In Vivo Sampling Division
West Lafayette Indiana
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)