PharmPK Discussion - Nimesulide parentral preparation

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On 4 Jan 2001 at 21:21:20, "Dr. Sudhir V. Dagaonkar" (drsudhir.at.bom2.vsnl.net.in) sent the message

I wish to know whether any internationally accepted Intramuscular injection
of Nimesulide is currently. How does one study its Pharmacokinetic
parameters?
Dr Sudhir V. Dagaonkar

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On 4 Jan 2001 at 23:55:06, bangarurk.-at-.drreddys.com sent the message

The following message was posted to: PharmPK
There is no parenteral form (injection) is available internationally. The
main reason is its insolubility in aqeous and non aqeuos media. It i
soluble only in alcohol at very percentage.
About the pharmacokinetics, data is available in the literature about the
pharmacokinetics generated in expt'l animals after parenteral route and in
humans after oral route. If you want to study the PK following I'M/IV route
you should have an acceptable formulation for use in humans.

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On 5 Jan 2001 at 10:48:59, "Froehlich, Enrico {PDC6~Basel}" (ENRICO.FROEHLICH.at.roche.com) sent the message

The following message was posted to: PharmPK
Dear colleague
Nimnesulide is marketed by HELSINN HEALTHCARE, Lugano, Switzerland.
The Medical Director of this company will certainly answer your
question.
Regards, Enrico Fr=F6hlich

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