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The following message was posted to: PharmPK
Dear readers,
Is it possible for a compound to have an oral bioavailability
(absolute) of near 1 and yet to see the presence of ~12% of
glucuronides and sulfate conjugates of that compound in the urine?
Thank you for any suggestions.
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The following message was posted to: PharmPK
hi
i guess it is possible. the drug when absorbed from the GIT is available
systemically (f=1)and then it depends on the drug itself, whether it could
form conjugates, most probably in the kidneys. well, kidneys do have the
ability to form conjugates where they could be excreted being more polar.
liver has a higher incidence for formation of conjugates, however, a
majority of which could be found in the bile and also the feces.
hope this helps you.
best wishes
manish issar
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The following message was posted to: PharmPK
I believe it is possible to see a relatively moderate amount of
glucuronides and sulfate conjugates in the urine. Both of these phase
II pathways are common and produce metabolites with higher
hydrophilicity, which then can be readily excreted in the urine.
Depending on the molecular weight, these metabolites can also be
significantly excreted into bile (higher MW are excreted in bile).
Sincerely,
David Jaworowicz
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)