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The following message was posted to: PharmPK
I work in drug discovery and development of lipophilic and amphiphilic
Many water insoluble drugs are used in medicine e.g. carbamazepine.
Part of them have serious problems with absorption, bioavailability, iv
In what cases increasing hydrophilicity of drug is crucial for its
What regular drugs need to improve water solubility?
Roman Kamburg Ph.D., M.D.
Pharmacology, Toxicology & Pharmacokinetics
Rabin Science Park
Rehovot 76121, Israel
Tel: 972-8-9463032, ext.233
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