PharmPK Discussion - Time above MIC ?

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On 10 Aug 2001 at 10:57:53, "suresh bl" (suresh_bl.aaa.hotmail.com) sent the message


The following message was posted to: PharmPK

Dear all,

I would like to know how to calculate the Time above MIC which is an
important pharmacodynamic parameter, for the oral dose study in
animals.

I have got the literature where they have specified the Time above
MIC values, but i really don't know how those numbers arrived, so if
any one gives me the detail about how to calculate, it will be of
great help.

Waiting for the early suggestions and comments,

Thanks,
B.L.Suresh

[By inspection? - db]

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On 13 Aug 2001 at 21:04:04, "Bert L. Lum" (bert.lum.at.coastside.net) sent the message


The following message was posted to: PharmPK

Mr. Suresh,

One way to determine the time above a threshold value is to fit the
data in a compartmental model to derive parameter estimates, then
simulate the concentration time data over a variety of time points.
This approach has been common with the anticancer drug, paclitaxel
(see Merrill Egorin's papers) using ADAPT. ADAPT is available for
free: http://www.usc.edu/dept/biomed/BMSR.

Bert Lum, Pharm.D.
Stanford University Clinical Cancer Center

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On 14 Aug 2001 at 14:42:49, Fabiana Landoni (landoni.-at-.fcv.medvet.unlp.edu.ar) sent the message


The following message was posted to: PharmPK

Dear Dr Suresh
Concerning PK/PD integration for antibiotics there are 3 important
parameters that can be used:

T>MIC is the time that serum or biological fluid concentration exceeds MIC
values. You can estimate this time looking up your concentration/time
graphs. This variable is highly correlated with success of treatment  only
for drugs exhibiting time-dependent activity (beta-lactams, erythromycin).

Cmax/MIC ratio: This parameter is useful only when working with
antibacterials exhibiting concentration-dependent activity
(aminoglycosides, fluoroquinolones).

AUC/MIC (AUIC): it is the area under the inhibitory serum concentration
time curve which can be measured as the reciprocal of the serum inhibitory
titre (SIT) versus time curve. It can also be estimated by AUC/MIC.  This
parameter is useful for drugs exhibiting concentration-dependent activity.

I hope it helps
Best wishes

Prof. Dra  Maria Fabiana Landoni, PhD
Catedra de Farmacologia.
Facultad de Ciencias Veterinarias
Universidad Nacional de La Plata
FAX +54-221-425-7980
Calle 60 y 118 cc 296
(1900) La Plata.
ARGENTINA

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