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I was reading about the methods to test the vitreal kinetics of
different drugs used in ocular therapy for retinal diseases a few days
back and it made me wonder about the enzymatic contents of vitreous
humor. Is human vitreous known to contain nuclease enzyme or any enzyme
which would be expected to cleave protein/oligo/macromolecules?
The first oligonucleotide approved by FDA happens to be for retinal
disease and it would be interesting to know how the enzymatic content of
vitreous affects the kinetics of this oligo once inside the vitreous
Any inputs will be appreciated.
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