PharmPK Discussion - Vitreal protein binding-altering kinetics

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On 20 Jul 2001 at 23:28:38, "Thirumurthy velpandian" (tvelpandian.-a-.hotmail.com) sent the message


The following message was posted to: PharmPK

  Dear friends

  I am working on the  kinetics of drugs injected intravitreally in
the eye.  Retinal pump mechanism  is a well known pathway by which
the injected drug cleared in to systemic circulation.  It is also
known that pump mechanism fails while the vitreous is infected or
inflamed during endophthalmitis. Despite being good concentration of
drug in the vitreous, the microbial kill is not accomplished in sight
threatening conditions. Therefore, a partial vitrectomy is done to
remove the microbial load.  In my experiments,   I have observed that
the vitreal protein-drug binding  could be  a contributing factor for
the less efficacy of  drug  when it is in the bound form. Being
collagen is a major protein in the vitreous, I am interested in
finding its relevance  in the kinetics of intravitreally injected
drugs. If anybody is having information regarding the same, please
let me know. Moreover, I am not able to quantify the collagen in the
vitreous by the conventional protein assays and specific
hydroxyproline assays.  Could any one help me.

Velpandian

Pharmacokinetics & TDM laboratory

Department of Pharmacology

All India Institute of Medical Sciences

New Delhi, India

tvelpandian.at.hotmail.com

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