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I am doing a kinetic model of aminoglycosides based on two compartments
with zero order input and first order elimination. Does anyone have
reference to what the micro or macroconstants would be for any of the
aminoglycosides?
Glenn Whelan, PharmD, Research Fellow
Nemours Children's Clinic
807 Children's Way
Jacksonville, FL 32250
email gwhelan.-a-.nemours.org
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Dear Glenn,
You can find a good general discussion on this topic in
Pharmacokinetics, Gibaldi and Perrier (1st Edition, Marcel Dekker,
1973, pp 69-77). In addition, please read the chapter on
aminoglycosides (Applied Pharmacokinetics by Evans, Schentag and
Jusko, Applied Therapeutics, 1992). Hope this is helpful.
Sri
Srikumaran K. Melethil, Ph.D., JD (2002)
Professor, Pharmaceutics and Medicine
University of Missouri- Kansas City
203B Katz Hall (School of Pharmacy)
Kansas City, MO 64110
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