- On 16 Aug 2002 at 13:04:41, "HUTMACHER, MATTHEW [Non-Pharmacia/1820]" (matthew.hutmacher.-a-.pharmacia.com) sent the message

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Hello everyone,

I have been asked to calculate the AUC(alpha) and AUC(beta) for a drug. I

have never explicitly heard of these terms. Has anyone have experience with

them? How do you calculate them noncompartmentally and/or compartmentally?

I have an idea of their purpose and how to calculate them, but your expert

opinions would be greatly appreciated.

Thanks.

Matt

[A/alpha for one and B/beta for the other? - db] - On 16 Aug 2002 at 15:33:26, "Davies, Brian {CLIN~Nutley}" (BRIAN.DAVIES.-at-.ROCHE.COM) sent the message

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It is not possible, as far as I know, to calculate them

noncompartmentally because you need to know the coefficients and

exponents of the biexponential model.

AUCalpha = A/alpha or C1/lambda1

AUCbeta = B/beta or C2/lambda2

Their use is to calculate the relative contributions of the two

phases of the profile to the clearance of the drug. If the terminal

phase is the dominant phase then AUCbeta will contribute the majority

of the total AUC. If AUCalpha is dominant then you have a drug which

is eliminated faster than its distribution and the terminal half-life

reflects distribution rather than elimination. In this case

calculation of an effective half-life from MRT x 0.693 is appropriate.

regards

Brian

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