PharmPK Discussion - Bayesian PK Software Survey

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On 10 Jul 2002 at 16:57:13, "Jones, Mike" (Mike.Jones.-at-.mdx.com) sent the message


Hi all,

A quick question for the clinicians in the group.  For those of you who use
Bayesian PK software programs in your clinical practice.  I would like to
know which programs you prefer to use to assist in dosing aminoglycosides,
vanco, theo, and digoxin.  If you have the manufacture's information handy
that also would be appreciated.

Thank you in advance for your assistance.

Mike
Mike Jones, Pharm.D.
Scientific Editor
Integrated Content/Clinical Decision Support
Micromedex / Thomson Healthcare
6200 S. Syracuse Way #300
Greenwood Village, CO 80111-4740
(303) 486-6723
1-800-525-9083 ext. 6723
mike.jones.at.mdx.com
www.micromedex.com/mlm.htm

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On 15 Jul 2002 at 08:55:34, "Rob Ariano" (RARIANO.-at-.sbgh.mb.ca) sent the message
```
I prefer Roger Jelliffe's USC*PACK programs at LAPK for bayesian
fitting.
Rob Ariano
```
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On 26 Jul 2002 at 10:43:16, Dimiter Terziivanov (terziiv.-a-.yahoo.com) sent the message


Dr. Jones,

	On 10 July you wrote:

>"Hi all,
>
>A quick question for the clinicians in the group.  For
>those of you who use Bayesian PK software programs in
>your clinical practice.  I would like to know which
>programs you prefer to use to assist in dosing
>aminoglycosides, vanco, theo, and digoxin".

	During the last 7 years I am working with USC*PACK
collectioin of PC programs (v.10.6) and I find it very
suitable for every day dosage adjustments in clinical
settings. The USC*PACK IT2B, an iterative two-stage
Bayesian population modeling program, allows for
elaborating proper population models for drugs of
interest for a given clinical ward . Moreover, the
Bayesian program is "able" to account for covariates
and to include assay errors in Bayesian forecasting.

	I find this software suitable for goal-and
patient-oriented drug therapy with narrow therapeutic
margins drugs in unstable risk patients. On the other
hand, the studies performed in the clinic I am working
with have demonstrated that IT2B method generates
consistent predictions even with unstable patients
(cirrhotics and RF patients) based on random and
suboptimal prior drug concentrations (Terziivanov, D.
et al 1998  Population pharmacokinetics of
ciprofloxacin in patients with liver impairments
analyzed by NPEM2 algorithm-a retrospective study. Int
J Clin Pharmacol Ther 36:376-382; Terziivanov, D. et
al 1999 Pharmacokinetic variability of nimodipine
disposition after single and multiple oral dosing to
hypertensive renal failure patients: parametric and
nonparametric population analysis. ibidem 37:404-412).

	Unfortunately, I have no own experience with other
softwares in the field and I can not suggest any
comparative features of USC*PACK IT2B program.

>"If you have the manufacture's information handy that
>also would be appreciated."

	For this kind of information you may contact Prof.
Roger W. Jelliffe at:

Roger W. Jelliffe, M.D. Professor of Medicine,
Laboratory of Applied Pharmacokinetics,
USC Keck School of Medicine
2250 Alcazar St, Los Angeles CA 90033, USA
email=jelliffe.aaa.hsc.usc.edu
Our web site=  http://www.lapk.org

Best regards,

Dimiter T.

Dimiter Terziivanov, MD,PhD,DSc, Professor
Clinic for Therapeutics and Clinical
Pharmacology, Univ Hosp "St. I.Rilsky",
15 D. Nestorov st, 1431 Sofia, Bulgaria
e-mal: terziiv.-a-.yahoo.com

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