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The following message was posted to: PharmPK
Does anyone know about the potential for beta-interferon to
down-regulate P450 3A4 (and/or other CYPS), and thus predict any likely
interactions with co-administered substrates for this enzyme? Also, is
ketoconazole the best inhibitor compound to use for 3A4 interaction
studies in heathy volunteers, or are there equally good inhibitors that
are better tolerated etc?
Thanks in advance for any help offered.
Dr David Critchley
+44 20 8600 1457
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