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Dear sir
I would be grateful to you if you send me the information regarding
"The estimation of absorption rate using deconvolution method"
With kind regards
Dr. Murali
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The following message was posted to: PharmPK At 08:29 AM 6/19/02, you wrote:
>I would be grateful to you if you send me the information regarding
>"The estimation of absorption rate using deconvolution method"
>
Deconvolution can provide a bioavailability rate, which may or may
not be the same as absorption rate, depending on first pass
extraction. First pass extraction is, in general, not a fixed
fraction or percent, but varies with time.
The problem can be complex, and simple methods like Wagner-Nelson and
Loo-Rigelman can provide some help, but may not reflect all of the
interactions taking place among transit, in vivo dissolution/release,
regionally dependent permeability, regionally dependent solubility,
saturable gut and hepatic metabolism, etc. Depending on your
objectives, you may need something more discriminating.
We use a method that you might call "deconvolution by convolution" -
fitting a sophisticated simulation model that includes absorption
(with all of its dependencies) and pharmacokinetics together to find
the most likely combination of parameters to explain the data.
Walt Woltosz
Chairman & CEO
Simulations Plus, Inc. (SIMU)
1220 W. Avenue J
Lancaster, CA 93534-2902
U.S.A.
http://www.simulations-plus.com
E-mail: walt.at.simulations-plus.com
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For deconvolution issues, I suggest you contact Claudio Cobelli
(cobelli.-at-.dei.unipd.it). He has done extensive work on deconvolution, and
has a prototype method implemented in Matlab.
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)