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Dear readers,
I remember that there were numerous discussions on this issue in general
in
the past. My question is about the presence of these humps on both IV
and oral
concentration time curves. If a drug undegoes enterohepatic recirculation
(among all other factors that could account for the presence of these
humps),
would these humps be expected(to the same extent)on BOTH iv and oral
curves or
just the oral concentration-time profile?
Thanks for your suggestions.
Panteha
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Hello Panteha
If a drug undergoes enterohepatic recirculation then it will show the
concentration time profile both after oral and intravenous as you
suggested.
One good example will be diclofenac.
The below references are good:
K Tabata, K Yamaoka, T Fukuyama, and T Nakagawa
Local absorption kinetics into the portal system using the portal- venous
concentration difference after an oral dose of diclofenac in the
awakening
rat. Accelerative effect of bile on intestinal absorption of diclofenac
Drug Metab Dispos 1996 24: 216-220.
T Fukuyama, K Yamaoka, Y Ohata, and T Nakagawa
A new analysis method for disposition kinetics of enterohepatic
circulation
of diclofenac in rats
Drug Metab Dispos 1994 22: 479-485.
Kojima, S., Nadai, M., Kitaichi, K., Wang, L., Nabeshima, T., Hasegawa,
T.
(1998). Possible Mechanism by Which the Carbapenem Antibiotic Panipenem
Decreases the Concentration of Valproic Acid in Plasma in Rats.
Antimicrob.
Agents Chemother. 42: 3136-3140
Venkatesh Atul Bhattaram
Post-doctoral Fellow
University of Florida
Gainesville-32610
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