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The following message was posted to: PharmPK
Dear collegues,
does anyone have any advice/experience regarding interspecies
differences in subcutaneous PK? We did some experiments with s.c
administration in different species (guinea-pig, monkeys, minipig) and
the results are a little bit puzzling. So we are not sure which is the
best (dermatological) species in order to extrapolate the data to human.
Any suggestion/information would be greatly appreciated.
Yours sincerely,
Olaf Kuhlmann
Olaf Kuhlmann, Ph.D.
F. Hoffmann-La Roche Ltd.
PRNS, Bldg. 69 / 156A
Grenzacherstr. 124
CH-4070 Basel (Switzerland)
Email: olaf.kuhlmann.at.roche.com
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The following message was posted to: PharmPK
Olaf:
I've heard that the minipig, particularly the skin under the forearms,
is supposed to provide the animal model with skin most analogous to
human skin. When I first heard this I imagined a pig examining its
underarm and thinking "Gee, I feel almost human today". But, I have no
specific references to offer. This opinion has been voiced by people
interested in percutaneous administration of drug, ointments,
transdermal patches, etc.
We've done work using in vivo ultrafiltration and/or dialysis probes in
the rat skin (subcutaneous or dermal-subdermal placement) to monitor
endogenous compounds (glucose) and compounds administered by a variety
of routes (oral, IV, IM, SC). I know you didn't ask about rats, but one
thing to consider is room temperature. If you have to shave the site to
place the probe, or to administer the compound (e.g. patch), you may
need to make sure that the animal stays even a little warmer than usual
because blood flow to the skin can be affected. It occurs to me that
there might be some housing variations among the species you're studying
that might influence blood flow to the skin and perhaps influence the
availability of drug after a subcu injection.
Candice Kissinger
In Vivo Sampling Laboratory
Bioanalytical Systems Inc.
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)