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Dear All,
I am looking for some references on measurement of Linezolid
concentrations in different biological fluids and tissues.
Would appreciate any help.
Sandeep
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Sandeep, you may want to consider doing a simple medline search
yourself as the first step, available for free at www.pubmed.gov,
which quickly revealed the following:
1. Tobin CM, Sunderland J, White LO, MacGowan AP. A simple, isocratic
high-performance liquid chromatography assay for linezolid in human
serum. J Antimicrob Chemother. 2001 Nov;48(5):605-8.
PMID: 11679548 [PubMed - indexed for MEDLINE]
2: Borner K, Borner E, Lode H. Determination of linezolid in human
serum and urine by high-performance liquid chromatography.
Int J Antimicrob Agents. 2001 Sep;18(3):253-8.
PMID: 11673038 [PubMed - indexed for MEDLINE]
3: Ehrlich M, Trittler R, Daschner FD, Kummerer K. A new and rapid
method for monitoring the new oxazolidinone antibiotic linezolid in
serum and urine by high performance liquid chromatography-integrated
sample preparation.
J Chromatogr B Biomed Sci Appl. 2001 May 5;755(1-2):373-7.
PMID: 11393729 [PubMed - indexed for MEDLINE]
4: Peng GW, Stryd RP, Murata S, Igarashi M, Chiba K, Aoyama H, Aoyama
M, Zenki T, Ozawa N. Determination of linezolid in plasma by reversed-
phase high-performance liquid chromatography.
J Pharm Biomed Anal. 1999 Jun;20(1-2):65-73.
I also understand that Chuck Peloquin's group has an assay available
for linezolid, and a website: http://www.njc.org/idpl.html
regards,
patrick smith
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)