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I am looking for some control data to validate a metabolic stability
screen in rat and human liver microsomes. Is anyone aware of literature
references describing the percent parent remaining following incubation
of control compounds with microsomal preparations? Any information in
both human and rat microsomes would be greatly appreciated.
Dave Eiznhamer
David A. Eiznhamer, Ph.D.
Assistant Director of Pharmacology and ADME MediChem Life Sciences
2501 Davey Road
Woodridge, IL 60517
P: (630) 783-4755
F: (630) 783-4646
deiznhamer.-a-.medichem.com
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Dear Dr. Eiznhamer:
A recently published article has some data on percent remaining of
parent after incubation with human and rat liver microsomes. Its by
Mandagere et al published in J med chem. 2002, 45, 304-311
Regards,
Azher M. Hussain, Ph.D
Post Doctoral Researcher
P450 Inhibition
Xenotech, LLC
deiznhamer.-at-.medichem.com 03/14/02 16:00 PM
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