- On 4 Sep 2002 at 23:14:12, "Aqel Abu-Qare" (aabu-qare.at.neophrm.com) sent the message

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What is the significance of MRT (Mean Residence Time) or AUMC?. Is

there a relationship between MRT and the half-life?

Regards,

Aqel - On 5 Sep 2002 at 11:00:24, "Willi Cawello" (Willi.Cawello.at.schwarzpharma.com) sent the message

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Please find this explanation of mean time parameters:

"The Concept of mean-time parameters

It is of interest to investigate how long on average drug molecules

stay in the body unchanged, initially without making a distinction

between elimination by excretion and elimination by metabolism.

Variability of these so-called residence times between different

molecules of the drug leads to a frequency distribution of residence

times which can be characterized, just like any other statistical

distribution, by its mean, variance and/or form of the frequency curve.

Among these para-meters the arithmetic mean of the individual residence

times, the "mean residence time" (MRT), is a parameter which is suitable

for characterizing the underlying pharmacokinetic processes."

A relationship between MRT and the half-life is given in general, but

only the iv adminstration in the one compartment model will have the

correlation between MRT and half-life. If there is an additional process

(e.g. absorption) MRT is a result of the combination of all the

processes of transports.

For more details please see my textbook 'Parameters for

Compartment-free Pharmacokinetics' (Shaker Publishing House, Aachen,

Germany 1999).

Willi Cawello, PhD

Senoir Scientist Pharmacokinetics

SCHWARZ BIOSCIENCES GmbH

Alfred Nobel Str. 10

D40789 Monheim am Rhein, Germany

willi.cawello.-a-.schwarzbiosciences.com

+02173 481480

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