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What is the significance of MRT (Mean Residence Time) or AUMC?. Is
there a relationship between MRT and the half-life?
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Please find this explanation of mean time parameters:
"The Concept of mean-time parameters
It is of interest to investigate how long on average drug molecules
stay in the body unchanged, initially without making a distinction
between elimination by excretion and elimination by metabolism.
Variability of these so-called residence times between different
molecules of the drug leads to a frequency distribution of residence
times which can be characterized, just like any other statistical
distribution, by its mean, variance and/or form of the frequency curve.
Among these para-meters the arithmetic mean of the individual residence
times, the "mean residence time" (MRT), is a parameter which is suitable
for characterizing the underlying pharmacokinetic processes."
A relationship between MRT and the half-life is given in general, but
only the iv adminstration in the one compartment model will have the
correlation between MRT and half-life. If there is an additional process
(e.g. absorption) MRT is a result of the combination of all the
processes of transports.
For more details please see my textbook 'Parameters for
Compartment-free Pharmacokinetics' (Shaker Publishing House, Aachen,
Willi Cawello, PhD
Senoir Scientist Pharmacokinetics
SCHWARZ BIOSCIENCES GmbH
Alfred Nobel Str. 10
D40789 Monheim am Rhein, Germany
PharmPK Discussion List Archive Index page
Copyright 1995-2010 David W. A. Bourne (firstname.lastname@example.org)