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What is the significance of MRT (Mean Residence Time) or AUMC?. Is
there a relationship between MRT and the half-life?
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Please find this explanation of mean time parameters:
"The Concept of mean-time parameters
It is of interest to investigate how long on average drug molecules
stay in the body unchanged, initially without making a distinction
between elimination by excretion and elimination by metabolism.
Variability of these so-called residence times between different
molecules of the drug leads to a frequency distribution of residence
times which can be characterized, just like any other statistical
distribution, by its mean, variance and/or form of the frequency curve.
Among these para-meters the arithmetic mean of the individual residence
times, the "mean residence time" (MRT), is a parameter which is suitable
for characterizing the underlying pharmacokinetic processes."
A relationship between MRT and the half-life is given in general, but
only the iv adminstration in the one compartment model will have the
correlation between MRT and half-life. If there is an additional process
(e.g. absorption) MRT is a result of the combination of all the
processes of transports.
For more details please see my textbook 'Parameters for
Compartment-free Pharmacokinetics' (Shaker Publishing House, Aachen,
Willi Cawello, PhD
Senoir Scientist Pharmacokinetics
SCHWARZ BIOSCIENCES GmbH
Alfred Nobel Str. 10
D40789 Monheim am Rhein, Germany
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Copyright 1995-2010 David W. A. Bourne (email@example.com)