PharmPK Discussion - Naive pool vs STS vs NONMEM vs USCPACK

PharmPK Discussion List Archive Index page

On 2 Sep 2002 at 09:04:42, Gan Siew Hua (shgan1.aaa.yahoo.co.uk) sent the message


Dear all,

Can somebody tell me briefly what is the difference
between the naive pooling method, Standard-Two Stage,
NONMEM & NPEM? Why do some strongly prefers the NONMEM
but others are for NPEM; (which one is more powerful)?

Thanking you all in advance,
Ms. Gan Siew Hua,
Pharmacology Department,
Universiti Sains Malaysia,
16150 Kubang Kerian,
Kelantan,
MALAYSIA

Back to the Top

On 2 Sep 2002 at 22:58:14, "atul" (bvatul.at.ufl.edu) sent the message


Hello

You might find these references interesting.

1. Patoux A, Bleyzac N, Boddy AV, Doz F, Rubie H, Bastian G, Maire P, Canal
P, Chatelut E.
Comparison of nonlinear mixed-effect and non-parametric expectation
maximisation modelling for Bayesian estimation of carboplatin clearance in
children.
Eur J Clin Pharmacol. 2001 Jul;57(4):297-303.

2:  Vermes A, Math t RA, van der Sijs IH, Dankert J, Guchelaar HJ.
Population pharmacokinetics of flucytosine: comparison and validation of
three models using STS, NPEM, and NONMEM.
Ther Drug Monit. 2000 Dec;22(6):676-87.

3:  Maire P, Barbaut X, Girard P, Mallet A, Jelliffe RW, Berod T.
Preliminary results of three methods for population pharmacokinetic analysis
(NONMEM, NPML, NPEM) of amikacin in geriatric and general medicine patients.
Int J Biomed Comput. 1994 Jun;36(1-2):139-41.

Venkatesh Atul Bhattaram
Post-doctoral Fellow
University of Florida
Gainesville-32610

Back to the Top

Want to post a follow-up message on this topic? If this link does not work with your browser send a follow-up message to PharmPK@boomer.org with "Naive pool vs STS vs NONMEM vs USCPACK" as the subject

PharmPK Discussion List Archive Index page