PharmPK Discussion - Non-linear kinetics

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On 23 Aug 2002 at 18:01:11, pkhalili (pkhalili.aaa.ualberta.ca) sent the message


Dear readers,
Thank you for all the useful comments and clarifications with this
regard (flip-flop kinetics).
I have an additional question and that is with regard to non-linear kinetics:
Is it possible that half-life estimated from the declining part of the oral
plasma-concentration profile is longer than that obtained following iv-bolus
administration of the same dose, due to the presence of non-linear kinetics at
that dose?

Thank you for any suggestions.

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On 26 Aug 2002 at 12:19:21, Joanne_Ma.-a-.vpharm.com sent the message


It is possible.  The best thing is to do IV PK study at different
dose and find out whether the compound shows linear or non-linear PK.

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On 26 Aug 2002 at 13:34:52, "Xiaofeng Wang" (xwang.aaa.innaphase.com) sent the message


half-life is only meaningful for linear kinetics (1st order).  If it is not
linear kinetics, half-life calculated from different concentration ranges
will be different.

xiaofeng

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