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i want to ask a question about Omeprazole . The question is "is
there any problem if we make solution or suspension of omeprazole in
sodium bicarbonate with regard to its absorption in intestine
(enteric coated ), If no problem then kindly give me reference (if
any) or any study available with respect to this .I will be very
grateful to you .
Please send me e-mail on this contact
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The answer to your question is "Yes". I would recommend that you use
lansoprazole suspension in 8.4% sodium bicarbonate (SLS) because clinical
study results have shown that SLS performs better than SOS (Simplified
Omeprazole Suspension) and even better than IV pantoprazole. Please see the
following two references and other relevant references noted in these two
papers. I am the corresponding author for the following two papers so if you
have questions, please let me know.
Wei-Jian Pan, Ph.D.
Clinical Pharmacokinetics (RD-2B)
2525 Dupont Drive
Irvine, CA 92612-1599
Doan, T. T.; Wang, Q.; Griffin, J. S.; Lukasik, N. L.; O'Dea, R. F. and Pan,
W. J.: Comparative pharmacokinetics and pharmacodynamics of lansoprazole
oral capsules and suspension in healthy subjects. American Journal of
Health-System Pharmacy 58:16, 1512-1519, 2001.
Taubel, J. J.; Sharma, V. K.; Chiu, Y. L.; Lukasik, N. L.; Pilmer, B. L. and
Pan, W. J.: A comparison of simplified lansoprazole suspension administered
nasogastrically and pantoprazole administered intravenously: effects on 24-h
intragastric pH. Alimentary Pharmacology & Therapeutics 15:11, 1807-1817,
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