PharmPK Discussion - Pediatric blood volume

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On 13 Jun 2002 at 16:25:10, Jeffrey Larson (jlarson.-a-.tanox.com) sent the message


Hi All

I am wondering if anyone has experience with clinical dosing of small
children, specifically regarding the blood volume.  Since small children are
percentage wise more water than adults, is the blood volume greater than
50-75 mL/kg or do you routinely use the high end of the estimated range for
adults?

Cheers!

Jeffrey L. Larson, Ph.D.
Director of Toxicology and Pharmacokinetics
Tanox, Inc.
4888 Loop Central Drive
Houston, TX  77081-2225
(713) 578-4212

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On 18 Jun 2002 at 16:08:38, "Dr. Sander Vinks" (sander.vinks.-a-.chmcc.org) sent the message


Jeffrey,

We use a total blood volume of 80 ml/kg (e.g. to calculate maximum
allowable blood volumes drawn for PK studies).

Regards

Alexander A. Vinks, PharmD, PhD,
Research Professor of Pediatrics
Cincinnati Children's Hospital and Medical Center
Pharmacology Research Center & Clinical Trials Office
CHRF 6506, MLC 7025
3333 Burnet Avenue
Cincinnati, Ohio 45229-3039

CHMCC email: sander.vinks.aaa.chmcc.org

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