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Dear collegues
I would very much appreciate information about a potential effect of
surfactants of the group polyoxyethylene stearates, on intestinal
membrane permeability. Do you think these substances can act as
permeation promoters of poorly absorbed drugs?.
Carlos Montuenga
Madrid Spain
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dear Carlos,
Yes the class of surfactant u are referring to can act as the
pemeability enhancers for poorly soluble drugs. Apart from this they
are also good paracellular permeability enhancers ,probabaly acting via
enhancing the fluidity of membrane.
Kind regards,
Pradeep S. Bhadauria
Ranbaxy research Laboratories
INDIA.
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dear carlos,
Please see the US patent application 20010008896 for your reference
wherein as a class polyoxyethelene fatty acid esters (Myr)are
described as solubilizing agent for the poorly soluble . I understand
if the drug is having dissolution rate dependent absorption like class
II drugs, there are fair chances you may get increased absorption ,at
least in terms of rate .
Does it work.
Kind regards,
Pradeep S. Bhadauria
RANBAXY REAEARCH LABORATORIES.
INDIA.
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Polysorbate 80 (Tween 80) is one of these polyoxyethylene fatty acid
esters.
The use of surfactants as permeation promoters is well-known. This kind
of
surface-active agent enhances the drug solubility (solubilizing agent)
and
also removes the mucosa from the intestinal membrane to enhance
absorption
as well (permeation promoter). The trouble with it is that mucosa
protects
the epithelium from irritancy and as you "clean" it with some
surfactants
ulcerations may appear in long-term treatments.
Regards,
Frederic DOC
PFIZER Global R&D
Fresnes Laboratories
FRANCE
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