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I am in process of conceptualizing and exploring the possibility of
developing a formulation system incorporating the drug normally
recommended in varying dose range by oral route of administration but
we are exploring the application by pulmonary route ( Local action on
bronchial network). It will be really helpful for us if somebody can
suggest any suitable model to extrpolate or predict the dose to be
delivered for the system to be therapeutically effect. We can share
the required therapeutic concentration for the activity and
percentage drug deposition targetted. Apart from this what other
paameter we need.
Even if we can get the model to extrpolate the dose from oral to
pulmonary administrtion considering the systemic effect is desired
will additionally be helpful.
Any help in this regard will be appreciated.
Pradeep S. Bhadauria
Dr. Reddy's Laboratories Limited
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