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The following message was posted to: PharmPK
Does anyone know of a "rule of thumb" relationship of Vz to Vss which
would allow you to distinguish between the terminal phase representing
elimination and the terminal phase representing distribution? eg if the
ratio of Vz:Vss is < 2, terminal phase is elimination; if the ratio is
>2, the terminal phase is distrribution. Assuming non-compartmental
analysis.
Alan
HUNTINGDON LIFE.SCIENCES LIMITED
http://www.huntingdon.com
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