PharmPK Discussion - Renal clearance

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On 10 Nov 2002 at 19:40:52, h2002032.aaa.bits-pilani.ac.in sent the message


Dear All,
can we calculate renal clearance using non-compartmental analysis?
if so what is the method for it and how to do it?
thank you in advance
SK.BASHA

		*SK.ABDUL MOHAMMED JAFAR SADIK BASHA*
		*2002H108032			    *	
		*Room No.: 230, Bhagirath Bhavan    *
		*BITS, Pilani                       *
		*Rajasthan                          *

[U(infinity)/Dose ? - db]

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On 11 Nov 2002 at 08:29:24, "Shoaf, Susan" (susans.at.otsuka.com) sent the message


All,
Renal clearance is Amount excreted in urine(0-t)/AUC(0-t) where if t is
long
enough and values approximates infinity then you substitute "inf
symbol" for
(0-t).

Fraction excreted is Amount excreted/Dose.

Percent Fraction excreted is above * 100.

Susan

Susan E. Shoaf, Ph.D.
Sr. Pharmacokineticist
Otsuka Maryland Research Institute
Rockville, MD

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On 11 Nov 2002 at 09:22:32, "Tom Dowling" (tdowling.-at-.rx.umaryland.edu) sent the message


BASHA:
You can calculate renal clearance as CLr = Ae(x-y)/AUC(x-y) where Ae is
the amount excreted in urine from time x to y, and AUC is the
corresponding AUC for the time period x to y.
Tom

Thomas C. Dowling, PhD, PharmD
Assistant Professor
Department of Pharmacy Practice and Science
Pharmacokinetics and Biopharmaceutics Laboratory
University of Maryland School of Pharmacy
100 N. Penn St., Rm. 540-D
Baltimore, MD 21201
Web: https://rxsecure.umaryland.edu/research/tdowling/

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