- On 10 Nov 2002 at 19:40:52, h2002032.aaa.bits-pilani.ac.in sent the message

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Dear All,

can we calculate renal clearance using non-compartmental analysis?

if so what is the method for it and how to do it?

thank you in advance

SK.BASHA

*SK.ABDUL MOHAMMED JAFAR SADIK BASHA*

*2002H108032 *

*Room No.: 230, Bhagirath Bhavan *

*BITS, Pilani *

*Rajasthan *

[U(infinity)/Dose ? - db] - On 11 Nov 2002 at 08:29:24, "Shoaf, Susan" (susans.at.otsuka.com) sent the message

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All,

Renal clearance is Amount excreted in urine(0-t)/AUC(0-t) where if t is

long

enough and values approximates infinity then you substitute "inf

symbol" for

(0-t).

Fraction excreted is Amount excreted/Dose.

Percent Fraction excreted is above * 100.

Susan

Susan E. Shoaf, Ph.D.

Sr. Pharmacokineticist

Otsuka Maryland Research Institute

Rockville, MD - On 11 Nov 2002 at 09:22:32, "Tom Dowling" (tdowling.-at-.rx.umaryland.edu) sent the message

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BASHA:

You can calculate renal clearance as CLr = Ae(x-y)/AUC(x-y) where Ae is

the amount excreted in urine from time x to y, and AUC is the

corresponding AUC for the time period x to y.

Tom

Thomas C. Dowling, PhD, PharmD

Assistant Professor

Department of Pharmacy Practice and Science

Pharmacokinetics and Biopharmaceutics Laboratory

University of Maryland School of Pharmacy

100 N. Penn St., Rm. 540-D

Baltimore, MD 21201

Web: https://rxsecure.umaryland.edu/research/tdowling/

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