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Dear all,
Does anybody know some references about the pharmacokinetics and
pharmacodynamics of SAMe (S-adenosylmethionine) in humans and animals?
Thanks in advance!
Best Regards,
Carolina Marino
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Hi Carolina,
Enclosed are a few references which may be helpful.
1:This reference is for intellectual amusement only! LP Benenson Y,
Paz-Elizur T, Adar R, Keinan E, Livneh Z, Shapiro E.
Programmable and autonomous computing machine made of biomolecules.
Nature. 2001 Nov 22;414(6862):430-4.
PMID: 11719800 [PubMed - indexed for MEDLINE]
2: Bottiglieri T.
S-Adenosyl-L-methionine (SAMe): from the bench to the bedside--molecular
basis
of a pleiotrophic molecule.
Am J Clin Nutr. 2002 Nov;76(5):1151S-7S. Review.
PMID: 12418493 [PubMed - indexed for MEDLINE]
3: Kaye GL, Blake JC, Burroughs AK.
Metabolism of exogenous S-adenosyl-L-methionine in patients with liver
disease.
Drugs. 1990;40 Suppl 3:124-8. Review.
PMID: 2081477 [PubMed - indexed for MEDLINE]
4: Morana A, De Rosa A, Carteni M, Parlato M, De Rosa M.
S-adenosyl-L-methionine N-ole-1-oyltaurate: pharmacokinetic of the
orally
administered salt in rats.
Int J Pharm. 2001 Nov 6;230(1-2):47-55.
PMID: 11672955 [PubMed - indexed for MEDLINE]
5: Stramentinoli G.
Pharmacologic aspects of S-adenosylmethionine. Pharmacokinetics and
pharmacodynamics.
Am J Med. 1987 Nov 20;83(5A):35-42. Review.
PMID: 3318439 [PubMed - indexed for MEDLINE]
6: Giulidori P, Cortellaro M, Moreo G, Stramentinoli G.
Pharmacokinetics of S-adenosyl-L-methionine in healthy volunteers.
Eur J Clin Pharmacol. 1984;27(1):119-21.
PMID: 6489422 [PubMed - indexed for MEDLINE]
7: Shivapurkar N, Poirier LA.
Tissue levels of S-adenosylmethionine and S-adenosylhomocysteine in
rats fed
methyl-deficient, amino acid-defined diets for one to five weeks.
Carcinogenesis. 1983 Aug;4(8):1051-7.
PMID: 6872150 [PubMed - indexed for MEDLINE]
8: Dell'Osso L, Placidi GF, Fornaro P, Cassano GB.
Fetal distribution of radiolabelled neuropsychopharmacological agents:
an
autoradiographic review study.
J Nucl Med Allied Sci. 1983 Jan-Mar;27(1):43-52. Review. No abstract
available.
PMID: 6134791 [PubMed - indexed for MEDLINE]
9: Finkelstein JD, Kyle WE, Harris BJ, Martin JJ.
Methionine metabolism in mammals: concentration of metabolites in rat
tissues.
J Nutr. 1982 May;112(5):1011-8.
PMID: 7077413 [PubMed - indexed for MEDLINE]
10: Gharib A, Sarda N, Chabannes B, Cronenberger L, Pacheco H.
The regional concentrations of S-adenosyl-L-methionine,
S-adenosyl-L-homocysteine, and adenosine in rat brain.
J Neurochem. 1982 Mar;38(3):810-5.
PMID: 7057194 [PubMed - indexed for MEDLINE]
11: Di Padova C, Tritapepe R, Cammareri G, Humpel M, Stramentinoli G.
S-adenosyl-L-methionine antagonizes ethynylestradiol-induced bile
cholesterol
supersaturation in humans without modifying the estrogen plasma
kinetics.
Gastroenterology. 1982 Feb;82(2):223-7.
PMID: 7054023 [PubMed - indexed for MEDLINE]
12: Okada G, Teraoka H, Tsukada K.
Multiple species of mammalian S-adenosylmethionine synthetase. Partial
purification and characterization.
Biochemistry. 1981 Feb 17;20(4):934-40.
PMID: 7213623 [PubMed - indexed for MEDLINE]
13: Okada G, Watanabe Y, Tsukada K.
Changes in patterns of S-adenosylmethionine synthetases in fetal and
postnatal
rat liver.
Cancer Res. 1980 Aug;40(8 Pt 1):2895-7.
PMID: 7388839 [PubMed - indexed for MEDLINE]
14: Liau MC, Chang CF, Giovanella BC.
Demonstration of an altered S-adenosylmethionine synthetase in human
malignant
tumors xenografted into athymic nude mice.
J Natl Cancer Inst. 1980 May;64(5):1071-5.
PMID: 6929012 [PubMed - indexed for MEDLINE]
15: Placidi GF, Stramentinoli G, Pezzoli C, Cassano GB.
A study of the distribution of radioactive S-adenosylmethionine in the
experimental animal.
Monogr Gesamtgeb Psychiatr Psychiatry Ser. 1978;18:100-10. No abstract
available.
PMID: 692530 [PubMed - indexed for MEDLINE]
16: Stramentinoli G, Catto E.
Pharmacokinetic studies of S-adenosyl-L-methionine (SAMe) in several
animal
species.
Pharmacol Res Commun. 1976 Apr;8(2):211-8. No abstract available.
PMID: 1028081 [PubMed - indexed for MEDLINE]
Sincerely,
Louis R. Ptak, Ph.D.
Senior Medical Writer
ICON Clinical Research, Inc.
212 Church Road
North Wales, Pennsylvania 19454
215-616-3507
ptakl.at.iconus.com
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