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I would like to scale up intrinsic in vitro metabolic clearances obtained on
mouse, rabbit and monkey hepatocytes, but I miss the corresponding
physiological scaling factors for these species (million cells per gram
liver). It is easy to find this value for the rat (ca. 125 106 cells/g
liver), the dog (ca. 240 106) and human (ca. 120 106), but I have no
reference paper for the others. Would anyone of you be able to help me ?
Many thanks in advance.
UCB Pharma, Belgium
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