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dear david
i am seeking of any method assay simvastatin in human
serum by using hplc becuase my research on phd on
method development also my studying bioavailbity of
simvastatin in human health, please help me and thank
you very very much.
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Dear Khaled, Asalam Alikum...
The following are some citations of HPLC assays developed for the
determination of Simvastatin in human plasma:
1. Simultaneous determination of simvastatin and its hydroxy acid form in
human plasma by high-performance liquid chromatography with UV detection.
J Pharm Biomed Anal. 1992 Sep;10(9):693-7.
Carlucci G, Mazzeo P, Biordi L, Bologna M.
Dipartimento di Chimica, Universita degli Studi dell'Aquila, Italy.
2. Determination of simvastatin and its active metabolite in human
plasma by
column-switching high-performance liquid chromatography with fluorescence
detection after derivatization with 1-bromoacetylpyrene.
J Chromatogr B Biomed Sci Appl. 1997 Jun 20;694(1):211-7.
Ochiai H, Uchiyama N, Imagaki K, Hata S, Kamei T.
Drug Metabolism, Development Research Laboratories, Banyu Pharmaceutical
Co., Ltd., Osato-gun, Saitama, Japan.
Please let me know if you were unable to get a copy of these publications
and I would be more happy to send you one.
Regards,
Khalid Alkharfy
PharmPK Discussion List Archive Index page
Copyright 1995-2010 David W. A. Bourne (david@boomer.org)