PharmPK Discussion - t1/2 greater than MRT?

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On 23 Aug 2002 at 10:37:25, "SK. Abdul Mohammed Jafar Sadik Basha" (h2002032.-at-.bits-pilani.ac.in) sent the message
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Can in any case MRT value be greater than t1/2? if so in what
circumstances it can be like that?

SK.ABDUL MOHAMMED JAFAR SADIK BASHA
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On 23 Aug 2002 at 19:16:39, Rostam Namdari (chista90.-at-.yahoo.com) sent the message


Dear Abdul,

Do you see this following iv bolus or iv infusion? Are
you dealing with a sustained released product?
A short answer to your question is yes; it may happen
when you are dealing with zero-order elimination
kinetic or when the early part of plasma
concentration-time curve drops very slowly (almost
like a sustained release profile) and later on shows a
mono-phasic kind of decline.

Rostam

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