PharmPK Discussion - Using WinNonlin to analyse the replicative design for individual BE and/or Pop BE

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On 5 Jun 2002 at 11:36:50, pyksk.-a-.mucc.mahidol.ac.th sent the message


Dear All,
Are there anybody having an experiences using the ANOVA in WinNonlin to do the
Pop BE and/or Individual BE? Is it possible to use the routine
function available in
WinNonlin to do a complicated mixed effect? Thank you for further
information and
details.
Best regards
Korbtham

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On 5 Jun 2002 at 13:05:36, Joseph Kim (JKim.-at-.Pharsight.com) sent the message


Dear Korbtham,
In the newer version of WinNonlin (version 3.2 and 3.3), you can do Pop BE
and Individual BE as well as Average BE.
The WinNonlin LinMix module includes the following options:

..	Random effects

..	Repeated effects

..	Model parameter estimates

..	Least squares means, with the standard errors automatically using
the correct error term

..	Differences of least squares means and their standard errors

..	Contrasts

..	Estimates

..	Sequential and Partial tests

..	Both classification and covariate variables in the model

..	No intercept option for the fixed effects model and for the random
model

..	Missing data

..	Soft transformations

..	Predicted and residual values

..	Weighted analyses

If you have any further questions, please contact us at
support.-a-.pharsight.com.

Thank you.

Joseph Kim, Ph.D., RPh.
Pharsight, Inc.
Scientific Support
5520 Dillard Drive Suite 210
Cary
NC
27511
USA
e-mail: jkim.-at-.pharsight.com

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