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We are currently running a clinical study concerning intra-individual
variability in sensitivity to warfarin (see our last publication at CPT
70, 159-164, 2001).
As part of this research, we plan to measure the vitamin K1 status of
our patients, namely, plasma levels of phylloquinone,
dihydrophylloquinone and it 2,3-epoxide.
As vitamin K-epoxide, dihydrophylloquinone and it internal standard
(substitution of a 25-carbon chain to menadione) are not commercially
available, we would like to ask for your help, in obtaining small
quantities of these compounds.
Thank you for your attention and help.
Shlomo Almog Ph.D
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