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Modelers: For those of you using the WinNonlin program, how do you deal with
input of baseline sample collections at a pre-dose time (where baseline is a
PD parameter that is decreased by a relative percent after dosing)? Do you
enter the sample collection time as 0 and the dose time as 0.01 or some
other trick to put the sample collection time before the dose time?
Jeffrey L. Larson, Ph.D.
Director of Toxicology and Pharmacokinetics
4888 Loop Central Drive
Houston, TX 77081-2225
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