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The following is my model output text, could anyone
explain to me what is the error message mean?
Input File: Data - [D:\WINNON~1\PBPK1106.WDO]
Start Time: 20:24:51 11-06-2002
End Time: 20:24:51 11-06-2002
WINNONLIN NONLINEAR ESTIMATION PROGRAM
(V01.1)
Core Version 26Mar96
Listing of input commands
MODEL
COMMANDS
nfun 4
NPARAMETERS 2
PNAMES 'ICN1''ICN2'
NDER 3
FNUM 2
END
1: TEMPORARY
2: T=X
3: VOL=0.00000209
4: Q=60000
5: VE=200
6: KBMX=0.0313
7: CL=0.00334
8: BMX=59.3
9: NSB=0.148
10: KD=0.00493
11: CE=Z(1)
12: CI1=Z(2)
13: CI2=Z(3)
14: BMAX=BMX*(1+KBMX*T)
15: F=1+NSB
16: G1=KD+BMAX+NSB*KD-CI1
17: H1=-CI1*KD
18: CIF1=(-G1+SQRT(G1**2-4*F*H1))/(2*F)
19: G2=KD+BMAX+NSB*KD-CI2
20: H2=-CI2*KD
21: CIF2=(-G2+SQRT(G2**2-4*F*H2))/(2*F)
22: IF T<=4 THEN
23: CP=77.034*EXP(-0.358*T)+10.232*EXP(-0.169*T)
24: ELSE CP=10.232*EXP(-0.169*T)
25: ENDIF
26: END
27: START
28: Z(1)=0
29: Z(2)=0
30: Z(3)=0
31: END
32: DIFF
33: DZ(1)=Q/VE*(CP-CE)+CL/VE*(CIF1-CE*0.05)*ICN1
34: DZ(2)=CL/VOL*(CE*0.05-CIF1)+CL/VOL*(CIF2-CIF1)
35: DZ(3)=CL/VOL*(CIF1-CIF2)
36: END
37: FUNC 1
38:
F=(Z(1)*VE+Z(2)*VOL*ICN1+Z(3)*VOL*ICN2)*853/1000000
39: END
40: FUNC 2
41: F=Z(1)*VE*853/1000000
42: END
43: FUNC 3
44: F=Z(2)*VOL*ICN1*853/1000000
45: END
46: FUNC 4
47: F=Z(3)*VOL*ICN2*853/1000000
48: END
49: EOM
SIMULATE
NVARIABLES 2
NPOINTS 100
XNUMBER 1
INITIAL 30000000,30000000
NOBOUNDS
MISSING 'Missing'
DATA 'WINNLIN.DAT'
BEGIN
*** ERROR 153 *** ONE OR MORE WEIGHTS BECAME
NEGATIVE. WEIGHT SET TO MISSING.
NORMAL ENDING
Thank you very much.
Sincerely
Dan
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