PharmPK Discussion - Accumulation and Fluctuation indexes

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On 26 Oct 2003 at 16:57:22, Ananda Sen (senuic.-a-.yahoo.com) sent the message


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I will appreciate in learning about Accumulation and
Fluctuation Indexes.  Can these be negative numbers?

If the Accumulation Index is a negative number, how
does it influence the development of a drug to be
delivered for chronic treatment?

I want to know more than what is given in Rowland and
Tozer, 1995.

Thanks
Ananda

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On 28 Oct 2003 at 15:10:47, "Sima Sadray" (sadrai.-a-.sina.tums.ac.ir) sent the message


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Dear Ananda,
No, k & Tau (dose interval) both can only have positive values, and so
the
exp(-k*tau) can never be larger than 1.
In a more precise formula (that you can find in Pharmacokinetics, second
edition, Gibaldi & Perrier, 1982,p121) the same rule applies.Only the
hybrid
elimination rate is used instead of k.

Best Regards,
Sima

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On 31 Oct 2003 at 17:14:14, "JVIS (Jennifer Visich)" (visichj.aaa.zgi.com) sent the message


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Accumulation indices cannot be negative numbers ..

Using the classic equation for a one compartment model..
R= 1/ (1-e^-kt)

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