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The following message was posted to: PharmPK
Can somebody suggest me what would be the best animal model to study
glucuronidation and drug interactions for the induction and inhibition
of
glucuronidation.
Thank you,
Sincerely,
Prasad
Prasad NV Tata, M.Pharm., Ph.D.
Mallinckrodt, Inc.
675 McDonnell Blvd.
Saint Louis, MO 63134-5840
Tel: (314) 654-5325
Fax: (314) 654-9325
e-mail: prasad.tata.aaa.tycohealthcare.com
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Hi,
Perhaps a rat model would be the best to test for drug interactions of
glucuronidation in animals. Be carefulthough, the Gunn rats
(mutantWistar rats)are deficient in UGT1A1 isoform and some other
UGT1A family isoforms, so they are not good for thatpurpose.
Similarly,cats are also deficient in some UGTs. Check UGTs web page
for more info about corresponding UGTs both in human and rat.
Hope this helps!
Khalid Alkharfy, Pharm.D., Ph.D.
Assistant Professor of Clinical Pharmaceutical Sciences
Department of Clinical Pharmacy
School of Pharmacy, KSU
VOICE: 01-467-7494
FAX: 01-467-7468
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The following message was posted to: PharmPK
The most economical and appropriate model is the Sprague Dawley rat
model.
Clapton Dias, Ph.D.
Pharmacokineticist II,
Global Product Development Services,
PRA International
16400 College Boulevard,
Lenexa, Kansas.
* 913-227-7257
6 913-599-2753
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The following message was posted to: PharmPK
The rabbit will be a good model to study glucuronidation. Its ability
for glucuronidation is comparable to that of man.
Regards,
Arthur Noach
Arthur B.J. Noach, Ph.D. Pharm.D.
Director Preclinical Research
Kinesis Holding BV
Consultants in Drug Development
Breda
The Netherlands
www.kinesis-pharma.com
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