- On 13 Mar 2003 at 08:28:25, "Aqel Abu-Qare" (aabu-qare.at.neophrm.com) sent the message

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In calculating AUC0-inf, WinNonlin use the formula: AUC0-inf=

AUC0-last+Clast/K, where Clast is the last measurable concentration and

K is the elimination rate constant. The question is does WinNonlin use

the same value of AUC0-last when calculating AUC0-inf. As an example if

AUC0-last = 100, dose this value is used to calculate AUC0-inf or a

different value?. Please let me know.

Regards,

Aqel Abu-Qare - On 13 Mar 2003 at 11:33:52, "Dan Weiner" (dlweiner.at.bellsouth.net) sent the message

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Dear Aqel - WinNonlin computes AUCinf in two ways. AUCinf(obs) uses the

last observed concentration for Clast while AUCinf(pred) used the

predicted concentration for Clast (based on the regression used to

estimate the terminal elimination rate, lambda z).

Dan Weiner - On 13 Mar 2003 at 11:02:01, "Ana Henry" (AHenry.-a-.Pharsight.com) sent the message

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Dear Dr. Abu-Qare,

The AUClast that is used to calculate AUC0-inf in WinNOnlin is in fact

the same value (100 in your example) reported as AUClast.

Ana Henry

PK Automation Specialist

Pharsight Corporation

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