PharmPK Discussion - Blood flow to bone

PharmPK Discussion List Archive Index page

On 24 Sep 2003 at 21:34:51, Jimmy Coulton (jimmy_coulton.-a-.yahoo.com) sent the message


Hi all,
Can anybodytell meabout the rate and extentof blood flow to the
bone with some references?
Thanks
Regards,
Jimmy

Back to the Top

On 26 Sep 2003 at 01:11:32, jbyczkowski.-at-.netscape.net sent the message

The following message was posted to: PharmPK

Jimmy Coulton  wrote:

> "...the rate and extent of blood flow to the
> bone with some references?...">>

Jimmy:

In general, in humans, allometrically scallable blood flow to bones
QboneC = 0.05 (fraction of cardiac output going to bone).
So, to calculate blood flow to bone over time QB (let's say in L per
hour), you have to multiply QboneC by cardiac output over the same time
QCG (L per hour):

                        QB=QboneC*QCG = 0.05*QCG
where * is multiplication.
A fraction of about 0.65 of QB goes to trabecular bone, while the rest
(0.35) to cortical bone.

For details, see:

O'Flaherty, E. J. (1991a). Physiologically based models for
bone-seeking elements: II. Kinetics of lead disposition in rats.
Toxicol. Appl. Pharmacol. 111, 313-331.

O'Flaherty, E. J. (1991b). Physiologically based models for
bone-seeking elements: III. Human skeletal and bone growth. Toxicol.
Appl. Pharmacol. 111, 332-341.

O'Flaherty, E. J. (1993). Physiologically based models for bone-seeking
elements: IV. Kinetics of lead disposition in humans. Toxicol. Appl.
Pharmacol. 118, 16-29.

O'Flaherty, E. J. (1995). Physiologically based models for bone-seeking
elements: V. Lead absorption and disposition in childhood. Toxicol.
Appl. Pharmacol. 131, 297-308.

O'Flaherty, E. J. (1998). A physiologically based model for lead in
children and adults. Environ. Health Perspect. 106, 1495-1503.

O'Flaherty, E. J. (2000). Modeling normal aging bone loss, with
consideration of bone loss in osteoporosis. Toxicol Sci. 55, 171-88.

Best wishes.

          Janusz Z. Byczkowski, Ph.D.,D.Sc.,D.A.B.T.
                          Consultant
                      212 N. Central Ave.
                      Fairborn, OH 45324
                      voice (937)878-5531
                   secure fax (702)446-9127
                     e-mail januszb.-at-.AOL.com
     homepage: http://members.aol.com/JanuszB/index.html
JZB Consulting web site: http://members.aol.com/JanuszB/consult.htm

Back to the Top

Want to post a follow-up message on this topic? If this link does not work with your browser send a follow-up message to PharmPK@boomer.org with "Blood flow to bone" as the subject

PharmPK Discussion List Archive Index page