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Can anybodytell meabout the rate and extentof blood flow to the
bone with some references?
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The following message was posted to: PharmPK
> "...the rate and extent of blood flow to the
> bone with some references?...">>
In general, in humans, allometrically scallable blood flow to bones
QboneC = 0.05 (fraction of cardiac output going to bone).
So, to calculate blood flow to bone over time QB (let's say in L per
hour), you have to multiply QboneC by cardiac output over the same time
QCG (L per hour):
QB=QboneC*QCG = 0.05*QCG
where * is multiplication.
A fraction of about 0.65 of QB goes to trabecular bone, while the rest
(0.35) to cortical bone.
For details, see:
O'Flaherty, E. J. (1991a). Physiologically based models for
bone-seeking elements: II. Kinetics of lead disposition in rats.
Toxicol. Appl. Pharmacol. 111, 313-331.
O'Flaherty, E. J. (1991b). Physiologically based models for
bone-seeking elements: III. Human skeletal and bone growth. Toxicol.
Appl. Pharmacol. 111, 332-341.
O'Flaherty, E. J. (1993). Physiologically based models for bone-seeking
elements: IV. Kinetics of lead disposition in humans. Toxicol. Appl.
Pharmacol. 118, 16-29.
O'Flaherty, E. J. (1995). Physiologically based models for bone-seeking
elements: V. Lead absorption and disposition in childhood. Toxicol.
Appl. Pharmacol. 131, 297-308.
O'Flaherty, E. J. (1998). A physiologically based model for lead in
children and adults. Environ. Health Perspect. 106, 1495-1503.
O'Flaherty, E. J. (2000). Modeling normal aging bone loss, with
consideration of bone loss in osteoporosis. Toxicol Sci. 55, 171-88.
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