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The following message was posted to: PharmPK
Hi:
Is there any way to get the blood volume of an animal
based on its weight? I am referring to a horse.
Thanks
Ananda
[7% ? - db]
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The following message was posted to: PharmPK
Ananda,
According to the textbook below, blood volume in horses would be 72
mL/kg body mass.
Regards,
Jerome del Castillo
Faculte de medecine veterinaire
Universite de Montreal
Swenson MJ. Physiological properties and cellular and chemical
constituents of blood. Ch. 2, p. 38. In: "Dukes' physiology of domestic
animals - 10th Ed." London, U.K. Cornell University Press (1984).
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The following message was posted to: PharmPK
Ananda,
You can predict the blood volume from a particular body weight by
allometric scaling. If you take the blood volume data from Davies &
Morris (1993) ("Physiological parameters in laboratory animals and
humans", Pharmaceutical Research 10, 1093-1095) and make an allometric
plot you should find a good (r-squared = 0.996) correlation. The
allometric coefficient is 72.447 and the exponent is 1.007.
So, blood volume (in mL) can be calculated from body weight (BW, in kg)
Volume = 72.447 x (BW ^ 1.007)
e.g. a 500 kg horse would have a predicted blood volume of 37,834 mL
(7.6%)
Since the allometric exponent is very close to 1.0 this supports Dave's
suggestion (and the assumption of most people) that the blood volume is
actually proportional to body weight. For the six species in the
Davies &
Morris article the blood volume varies from 5.4 - 9.0% of body weight.
The
mean value is 7.4%.
So, you can use the allometric approach, the %BW approach or maybe a
value
is available in another physiological table.
All the very best,
Bernard
Bernard Murray, Ph.D.
Senior Research Investigator
Drug Metabolism, PCS, PPD, GPRD, Abbott Laboratories, Chicago, USA
Bernard.Murray.at.abbott.com
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The following message was posted to: PharmPK
Dear Amanda,
I had to deal with this recently, so based on a
document published by Canadain Concile of Animal Care
blood volume in hourse is about 75-100 mL/kg body
weight. Hope this helps.
Rostam
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The following message was posted to: PharmPK
Hinchcliff et al (1991) in "Furosemide-induced changes in plasma and
blood volume of horses" in the Journal of Veterinary Pharmacology and
Therapeutics 14: 411-417 reported a blood volume of 90.3 (+/- 5.1)
mL/kg of body weight. Blood volumes were estimated by the Evans Blue
dye procedure.
Rick
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