# PharmPK Discussion - Blood volume based on weight

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• On 23 Jul 2003 at 14:40:39, Ananda Sen (senuic.aaa.yahoo.com) sent the message
`The following message was posted to: PharmPKHi:Is there any way to get the blood volume of an animalbased on its weight?  I am referring to a horse.ThanksAnanda[7% ? - db]`
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• On 24 Jul 2003 at 09:19:35, "Del Castillo Jerome" (jerome.del.castillo.-at-.umontreal.ca) sent the message
`The following message was posted to: PharmPKAnanda,According to the textbook below, blood volume in horses would be 72mL/kg body mass.Regards,Jerome del CastilloFaculte de medecine veterinaireUniversite de MontrealSwenson MJ. Physiological properties and cellular and chemicalconstituents of blood. Ch. 2, p. 38. In: "Dukes' physiology of domesticanimals - 10th Ed." London, U.K. Cornell University Press (1984).`
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• On 24 Jul 2003 at 10:08:28, Bernard.Murray.at.abbott.com sent the message
`The following message was posted to: PharmPKAnanda,You can predict the blood volume from a particular body weight byallometric scaling.  If you take the blood volume data from Davies &Morris (1993) ("Physiological parameters in laboratory animals andhumans", Pharmaceutical Research 10, 1093-1095) and make an allometricplot you should find a good (r-squared = 0.996) correlation.  Theallometric coefficient is 72.447 and the exponent is 1.007.So, blood volume (in mL) can be calculated from body weight (BW, in kg)Volume = 72.447 x (BW ^ 1.007)e.g. a 500 kg horse would have a predicted blood volume of 37,834 mL(7.6%)Since the allometric exponent is very close to 1.0 this supports Dave'ssuggestion (and the assumption of most people) that the blood volume isactually proportional to body weight.  For the six species in theDavies &Morris article the blood volume varies from 5.4 - 9.0% of body weight.Themean value is 7.4%.So, you can use the allometric approach, the %BW approach or maybe avalueis available in another physiological table.All the very best,BernardBernard Murray, Ph.D.Senior Research InvestigatorDrug Metabolism, PCS, PPD, GPRD, Abbott Laboratories, Chicago, USABernard.Murray.at.abbott.com`
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• On 24 Jul 2003 at 10:15:29, Rostam Namdari (chista90.aaa.yahoo.com) sent the message
`The following message was posted to: PharmPKDear Amanda,I had to deal with this recently, so based on adocument published by Canadain Concile of Animal Careblood volume in hourse is about 75-100 mL/kg bodyweight. Hope this helps.Rostam`
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• On 24 Jul 2003 at 16:16:08, Richard Sams (sams.-a-.mail.atl.ohio-state.edu) sent the message
`The following message was posted to: PharmPKHinchcliff et al (1991) in "Furosemide-induced changes in plasma andblood volume of horses" in the Journal of Veterinary Pharmacology andTherapeutics 14: 411-417 reported a blood volume of 90.3 (+/- 5.1)mL/kg of body weight. Blood volumes were estimated by the Evans Bluedye procedure.Rick`
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